Figure 4

Serum protein concentrations during acute hospitalization at multiple time points. Serum insulin growth factor-I (IGF-I) was significantly increased in the <40% and 40–59% total body surface area (TBSA) burn groups compared with the 60–79% and >80% TBSA burn groups 21–40 days postburn. At the later time point, serum insulin like growth factor binding protein-3 (IGFBP-3) was significantly higher in the <40% and 40–59% TBSA burn groups when compared with the other two burn groups. Serum growth hormone (GH) markedly decreased in burns of >40% TBSA and was significantly higher in burns of <40% TBSA. Serum insulin was significantly increased in large burns immediately after burn compared with the small burns. Urine cortisol was increased during the acute stay in all four groups. Urine cortisol, however, was significantly lower in the <40% TBSA burn group when compared with the other three groups. *Significant difference between >80% TBSA burn group versus <40% TBSA burn group, P < 0.05. ^†Significant difference 60–79% TBSA burn group versus <40% TBSA burn group, P < 0.05. Normal levels: IGF-I, 220–260 pg/ml; IGFBP-3, 3,800–4,200 pg/ml; GH, 6 pg/ml; insulin, 10–25 mg/dl; and urine cortisol, 20–45 μg/24 hours.