Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment

Table 1 Physiologic conditions at the beginning and end of ventilation

	Nonventilated		Tidal volume 30 ml/kg
	Room air	Hyperoxia	Room air	Hyperoxia
pH	7.40 ± 0.03	7.35 ± 0.01	7.33 ± 0.04	7.35 ± 0.03
PaO₂ (mmHg)	98.7 ± 0.4	421.3 ± 5.3	86.1 ± 0.8	409.1 ± 4.1
PaCO₂ (mmHg)	40.2 ± 0.3	39.1 ± 0.8	35.3 ± 1.4	43.1 ± 1.8
mean arterial pressure (mmHg)
Start	86 ± 1.3	85.3 ± 2.1	84.6 ± 1.6	83.0 ± 2.8
End	85.2 ± 0.7	84.8 ± 0.9	73.5 ± 5.0	71.9 ± 4.3
Evans blue dye (ng/mg lung weight)	14.1 ± 1.3	15.9 ± 2.1	76.8 ± 4.7*	165.3 ± 7.9*

Arterial blood gases, mean arterial pressure, and Evans blue dye analysis of normal nonventilated mice and of mice placed on either room air or hyperoxia for 5 hours (n = 10/group). *P < 0.05 versus control, nonventilated mice.

ISSN: 1364-8535