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Figure 5 | Critical Care

Figure 5

From: Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment

Figure 5

Akt mutants protected from hyperoxia effects on stretch-induced Akt and endothelial nitric oxide synthase activation. Phosphorylated serine/threonine kinase/protein kinase B (Akt) or endothelial nitric oxide synthase (eNOS) expressions ((a) and (b), top panel), total Akt or eNOS protein expressions ((a) and (b), middle panel), and relative phosphorylation quantitation by arbitrary units ((a) and (b), bottom panel) were obtained from control nonventilated mice and from mice ventilated with tidal volume 30 ml/kg while breathing room air or hyperoxia for 1 hour (n = 6/group). L-NAME was given intraperitoneally (15 mg/kg) 1 hour before ventilation. WT, wild-type C57BL/6 mice; RA, mice with room air; O2, mice with hyperoxia. *P < 0.05 versus control, nonventilated mice; †P < 0.05 versus all other groups.

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Critical Care

ISSN: 1364-8535