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Figure 4 | Critical Care

Figure 4

From: Involvement of Akt and endothelial nitric oxide synthase in ventilation-induced neutrophil infiltration: a prospective, controlled animal experiment

Figure 4

LY294002 reduced lung stretch-induced Akt and endothelial nitric oxide synthase activation. Mice ventilated at a tidal volume (VT) of 30 ml/kg for 1 hour were pretreated with 5 μg/g LY294002 intraperitoneally 1 hour before ventilation. Phosphorylated serine/threonine kinase/protein kinase B (Akt) or endothelial nitric oxide synthase (eNOS) expression ((a) and (b), top panel), total Akt or eNOS protein expression ((a) and (b), middle panel), and relative phosphorylation quantitation by arbitrary units ((a) and (b), bottom panel) (n = 6/group). *P < 0.05 versus control, nonventilated mice; †P < 0.05 versus ventilation with LY294002.

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Critical Care

ISSN: 1364-8535