Figure 1

Longitudinal relative blood mitochondrial DNA (mtDNA)/nuclear DNA (nDNA) ratio. Of the 28 critically ill subjects, survivors are presented in (a) and non-survivors in (b). Patients admitted with septic shock are represented by circles, those with cardiogenic shock by squares, and the hypovolemic patient by a triangle. Patients belonging to the four antioxidant treatment groups are distinguished by the color of their symbol (white, light grey, dark grey and black). Males are represented by a solid line and females by a dashed line. The thick lines represent the linear modeling of the mean mtDNA/nDNA slopes for the short-term survivors (N = 16, solid line) and the non-survivors (N = 12, dashed line) over the first 14 days after enrollment. Though the entire duration of data collected is shown on the graph, only data collected up to the first 14 days are used in the linear model shown here. ICU, intensive care unit.