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Table 2 Results of the inflammatory mediators and cardiac troponin I

From: Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations

  t1 t2 t3 t4 t5 t6 p
C-reactive protein (mg/l)
   Group A 3.7 (1.0–22.6)     79.9 (50.0–131.7) 112.0 (61.1–177.6) <0.001
   Group B 2.6 (0.6–10.5)     87.6 (52.4–143.0) 131.0 (71.0–228.0) <0.001
  p = 0.068*     p = 0.092* p = 0.168*  
IL-6 (pg/ml)        
   Group A 1.6 (0.4–21.8)   95.0 (13.6–405.1) 46.3 (16.1–149.5)    <0.001
   Group B 2.0 (0.4–60.6)   130.5 (21.7–353.8) 49.2 (14.8–214.5)    <0.001
  p = 0.107*   p = 0.829* p = 0.482*    
IL-6r (ng/ml)        
   Group A 43.6 (1.7–125.0)   47.4 (0.7–109.5) 56.2 (25.2–226.3)    0.949
   Group B 40.7 (15.6–94.6)   42.4 (22.2–100.5) 50.2 (13.2–104.9)    0.861
  p = 0.607*   p = 0.914* p = 0.304*    
IL-10 (pg/ml)        
   Group A 1.9 (0.2–24.0) 47.2 (2.3–476.6) 7.2 (1.3–90.9)     <0.001
   Group B 2.6 (0.8–9.7) 209.7 (16.3–814.3) 56.1 (3.6–225.1)     <0.001
  p = 0.136* p = 0.001* p = 0.001*     
Soluble endothelial leukocyte adhesion molecule-1 (ng/ml)
   Group A 88.6 (49.8–194.5)    88.5 (14.4–189.6) 72.7 (8.9–163.1)   0.058
   Group B 49.0 (18.3–144.1)    130.7 (33.0–360.7) 72.6 (16.7–224.7)   <0.001
  p < 0.001*    p = 0.033* p = 0.957*   
Cardiac troponin-I (ng/ml)
   Group A 0.02 (0.01–0.022)     0.22 (0.07–0.85) 0.13 (0.03–0.75) <0.001
   Group B 0.01 (0.01–0.016)     0.66 (0.10–1.28) 0.19 (0.03–0.80) <0.001
  p = 0.520*     p = 0.018* p = 0.097*  
  1. Data presented as the median (range). t1, before anaesthesia; t2, 10 minutes after cardiac surgery on cardiopulmonary bypass (CPB); t3, 2 hours after CPB; t4, 4 hours after CPB; t5, 24 hours after CPB; t6, 44 hours after CPB. Intraindividual differences (Friedman test), *between-group differences (Kruskal–Wallis test).