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Table 3 Peak and Mean uNGAL concentrations by pRIFLEmax status

From: Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study

Measurement

Control

pRIFLEmax R

pRIFLEmax I

pRIFLEmax F

Mean uNGALa

    

   ng/mg creatinine

0.5 ± 1.5/0.1 (0.2)

0.6 ± 0.9b/0.3 (0.9)

1.7 ± 2.6b/0.7 (1.8)

2.8 ± 3.0b,c/1.5 (4.2)

   ng/ml

14.2 ± 27.2/5.3 (13.2)

20.9 ± 28.1/11.6 (27.5)

58.9 ± 86.6b/20 (71.4)

82.7 ± 92.5b,c/35.0 (76.3)

Peak uNGALa

    

   ng/mg creatinine

0.8 ± 2.0/0.2 (0.4)

1.0 ± 1.5b/0.4 (1.2)

2.5 ± 3.8b/0.9 (1.9)

3.8± 3.8b,c/1.8 (5)

   ng/ml

24.6 ± 45.5/7.9 (20.0)

34.5 ± 47.4/14.7 (40.5)

82.9 ± 122.9b/25.0 (70.0)

103.2 ± 107.3b,c/55.0 (105.0)

  1. Values are expressed as mean ± standard deviation/median (interquartile range). aMean and peak urine neutrophil gelatinase-associated lipocalin (uNGAL) concentrations increased with worsening pRIFLEmax acute kidney injury (AKI; all P < 0.0002, Kruskal-Wallis test), whether expressed in ng/mg creatinine or ng/ml. These relationships were also statistically significant when examined by one-way analysis of variance (P < 0.0001). bMean and peak uNGAL expressed in ng/mg creatinine was higher in patients with pRIFLEmax R, I and F AKI than in control patients (all P < 0.05, Mann-Whitney test); mean and peak uNGAL expressed in ng/ml was higher in patients with pRIFLEmax R, I, and F AKI than in control patients (all P < 0.05, Mann-Whitney test). cMean and peak uNGAL was higher in patients with pRIFLEmax F AKI than in those with pRIFLEmax R and I AKI (all P < 0.05, Mann-Whitney test), whether expressed in ng/mg creatinine or in ng/ml. pRIFLEmax, the worst pRIFLE stratum attained; pRIFLE, pediatric modified Risk, Injury, Failure, Loss, End Stage Kidney Disease.