Skip to main content

Table 6 Functional outcome data in patients with malignant middle cerebral artery infarction: studies with comparative data on conservative treatment versus decompressive surgery

From: Clinical review: Therapy for refractory intracranial hypertension in ischaemic stroke

Authors Patients treated with conservative treatment Patients treated with decompression Mean age (years) Dominant/nondominant hemisphere + ACA and/or PCA Mean time to surgery (hours) Mean time to follow-up (months) Independent outcome Mild to moderate disability Severe disability Death
Delashaw et al., 1990 [118] 4   NA 100%/0% NA NA NA 0% 0% 0% 100%
   9 57 0%/100% 56% NA 15 22% 22% 44% 11%
Steiger 1991 [119] 7   NA NA NA NA 6 0% 0% 0% 100%
   8 NA NA NA NA 6 75% 75% 75% 25%
Rieke et al., 1995 [77] 55   56 62%/38% 22% NA 1 22% 22% 22% 78%
Hacke et al., 1996 [3]   63 50 17%/83% 35% 30 3 2% 40% 33% 25%
Wirtz et al., 1997 [104]            
Schwab et al., 1998 [109]            
Mori et al., 2001 [120] 21   72 52%/48% 33% NA 6 5% 0% 24% 71%
Mori et al., 2004 [111]   50 65 26%/74% 36% 63 6 10% 10% 56% 24%
Kuroki et al., 2001 [121] 7   80 NA NA NA NA 14% 14% 14% 86%
   8 72 NA NA NA NA 87% 87% 87% 13%
Holtkamp et al., 2001 [114] 12   73 83%/17% 67% NA 9 0% 0% 17% 83%
   12 65 25%/75% 42% 42 5 0% 0% 67% 33%
Cho et al., 2003 [115] 10   64 60%/40% 50% NA 6 20% 20% 20% 80%
   42 63 52%/48% 38% 50 6 71% 71% 71% 29%
Maramattom et al., 2004 [116] 10   63 40%/60% 0% NA 1 0% 10% 30% 60%
   14 55 22%/78% 71% 36 1 0% 38% 63% 0%
Yang et al., 2005 [122] 14   66 43%/57% 57% NA 3 0% 0% 36% 64%
   10 59 30%/70% 60% 62 3 10% 30% 50% 10%
Wang et al., 2006 [117] 41   67 56%/44% NA NA 6 0% 25% 54% 22%
   21 62 38%/62% NA 48 6 0% 14% 57% 29%
Authors Patients treated with hypothermia Patients treated with decompression Mean age (years) Dominant/nondominant hemisphere + ACA and/or PCA Mean time to surgery (hours) Mean time to follow-up (months) Independent outcome Mild to moderate disability Severe disability Death
Georgiadis et al., 2002 [124] 19   56 100%/0% 26% NA NA NA NA NA 47%
   17 52 0%/100% 24% 30 NA NA NA NA 12%
Authors Patients treated with decompression + hypothermia Patients treated with decompression Mean Age (years) Dominant/nondominant hemisphere + ACA and/or PCA Mean time to surgery (hours) Mean time to follow-up (months) Independent outcome Mild to moderate disability Severe disability Death
Els et al., 2006 [125] 12   49 NA NA 15 6 92% (median mRS 2)    8%
   13 49 NA NA 15 6 88% (median mRS 3)    12%
  1. Functional outcome was classified as described in Table 2. ACA, anterior cerebral artery; NA, not available; PCA, posterior cerebral artery.