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Table 3 Functional outcome data on patients with malignant middle cerebral artery infarction treated with hypothermia

From: Clinical review: Therapy for refractory intracranial hypertension in ischaemic stroke

Authors Number Mean age (years) Dominant/nondominant hemisphere + ACA and/or PCA Mean time to hypothermia (hours) Mean time to follow-up (months) Independent Mild to moderate disability Severe disability Death
Schwab et al., 1998 [95] 25 49 68%/32% 20% 14 3   Median Barthel Index 70   48%
Schwab et al., 2001 [134] 50 57 NA 10% 22 3   NA   38%
Georgiadis et al., 2001 [99] 6 65 83%/17% NA 28 NA NA NA NA 17%
Milhaud et al., 2005 [94] 10 52 50%/50% 8% 11 6 10% 30% 10% 50%
  1. Functional outcome was classified according to Gupta and colleagues [123] as (1) independent outcome (modified Rankin Scale [mRS] 0 to 1, Glasgow Outcome Scale [GOS] 5, Barthel Index [BI] greater than or equal to 90), (2) mild to moderate disability (mRS 2 to 3, GOS 4, BI 60 to 85), (3) severe disability (mRS 4 to 5, GOS 2 to 3, BI less than 60), and (4) death. In the case of patients in whom more than one outcome scale was given, we classified outcome according to the following priority: mRS – GOS – BI. NA indicates data not given or values of the BI, GOS, or mRS given as means [135,136]. ACA, anterior cerebral artery; PCA, posterior cerebral artery.