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Table 1 Effect of telithromycin on cytokine levels in bronchoalveolar lavage and plasma in a mouse respiratory inflammation model

From: Inhibition by telithromycin of systemic and respiratory inflammation induced by endotoxin in mice

Treatment

TNFα in BAL (pg/ml)

MIP-2 in BAL (pg/ml)

MIP-2 in plasma (pg/ml)

None

11 ± 6

41 ± 3

1 ± 4

TEL

9 ± 4

28 ± 2

0 ± 0

LPS

2846 ± 369

1637 ± 254

40 ± 10

TEL + LPS

1279 ± 285a

1020 ± 240b

24 ± 5c

  1. aP < 0.005, significantly different from mice treated with LPS alone.
  2. bP < 0.001, significantly different from mice treated with LPS alone.
  3. cP < 0.05, significantly different from mice treated with LPS alone.
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Critical Care

ISSN: 1364-8535