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Table 3 Dosing of opioids and sedative drugs at different time points

From: Mechanical ventilation with lower tidal volumes does not influence the prescription of opioids or sedatives

 

Before intervention

n

After intervention

n

P value

Morphine

     

   Day 1

0.54 ± 0.68

23

0.70 ± 0.85

38

0.55

   Day 7

0.64 ± 0.99

11

0.49 ± 0.66

20

0.74

   Day 14

0.53 ± 0.67

7

0.65 ± 0.72

8

0.90

   Day 21

0.88 ± 0.78

3

0.06 ± 0.13

5

0.21

   Day 28

0.25 ± 0.36

2

0.50 ± 0.81

3

0.67

Midazolam

     

   Day 1

0.65 ± 1.0

23

0.84 ± 1.3

38

0.94

   Day 7

0.82 ± 1.9

11

0.69 ± 1.8

20

0.80

   Day 14

0.32 ± 0.58

7

1.7 ± 3.5

8

0.45

   Day 21

0.40 ± 0.70

3

3.8 ± 8.6

5

0.42

   Day 28

0.37 ± 0.52

2

6.0 ± 10.4

3

0.45

Propofol

     

   Day 1

19.4 ± 35.3

23

13.5 ± 22.6

38

0.64

   Day 7

3.0 ± 8.2

11

13.9 ± 29.8

20

0.49

   Day 14

10.6 ± 27.8

7

21.8 ± 49.2

8

1.0

   Day 21

24.6 ± 42.5

3

52.3 ± 97.6

5

0.60

   Day 28

7.9 ± 11.2

2

32.0 ± 55.4

3

0.63

  1. Data are presented in mg/kg per day as mean ± standard deviation. The P value was derived using the Student's t-test.