| Before intervention | n | After intervention | n | P value |
---|---|---|---|---|---|
Morphine | Â | Â | Â | Â | Â |
   Day 1 | 0.54 ± 0.68 | 23 | 0.70 ± 0.85 | 38 | 0.55 |
   Day 7 | 0.64 ± 0.99 | 11 | 0.49 ± 0.66 | 20 | 0.74 |
   Day 14 | 0.53 ± 0.67 | 7 | 0.65 ± 0.72 | 8 | 0.90 |
   Day 21 | 0.88 ± 0.78 | 3 | 0.06 ± 0.13 | 5 | 0.21 |
   Day 28 | 0.25 ± 0.36 | 2 | 0.50 ± 0.81 | 3 | 0.67 |
Midazolam | Â | Â | Â | Â | Â |
   Day 1 | 0.65 ± 1.0 | 23 | 0.84 ± 1.3 | 38 | 0.94 |
   Day 7 | 0.82 ± 1.9 | 11 | 0.69 ± 1.8 | 20 | 0.80 |
   Day 14 | 0.32 ± 0.58 | 7 | 1.7 ± 3.5 | 8 | 0.45 |
   Day 21 | 0.40 ± 0.70 | 3 | 3.8 ± 8.6 | 5 | 0.42 |
   Day 28 | 0.37 ± 0.52 | 2 | 6.0 ± 10.4 | 3 | 0.45 |
Propofol | Â | Â | Â | Â | Â |
   Day 1 | 19.4 ± 35.3 | 23 | 13.5 ± 22.6 | 38 | 0.64 |
   Day 7 | 3.0 ± 8.2 | 11 | 13.9 ± 29.8 | 20 | 0.49 |
   Day 14 | 10.6 ± 27.8 | 7 | 21.8 ± 49.2 | 8 | 1.0 |
   Day 21 | 24.6 ± 42.5 | 3 | 52.3 ± 97.6 | 5 | 0.60 |
   Day 28 | 7.9 ± 11.2 | 2 | 32.0 ± 55.4 | 3 | 0.63 |