Table 1 Surrogate vs. clinical outcomes
From: Steroids in late ARDS?
Intervention | Disease | Surrogate | Clinical Outcome |
|---|---|---|---|
Growth hormone | Critical illness | ↑ nitrogen balance | ↑ mortality [13] |
Milrinone | CHF | ↑ exercise | ↑ mortality [14,15] |
Flecanide | Post-AMI | ↓ arrhythmias | ↑ mortality [16,17] |
Transfusion | ICU anemia | ↑ hematocrit | ↑ mortality [18] |
Inhaled nitric oxide | ARDS | ↑ oxygenation | No mortality benefit [19] |
Surfactant | ARDS | ↑ oxygenation | No mortality benefit [20] |