Table 4 Reported adverse events

Surfactant (n = 157)

Control (n = 150)

Luchetti, 1998

'No adverse haemodynamic effects were noted'

'No complications were reported in either group'

'No complications were reported in either group'

Willson, 1999

One with transient bronchospam

One with air leak

Two with air leaks

One with air leak and pulmonary interstitial emphysema

One with pulmonary interstitial emphysema

One plugged endotracheal tube

Tibby, 2000

'No complications were noted after surfactant administration'

Not reported

Luchetti, 2002

'No complications due to the treatment were observed in the surfactant-treated group'

'... no complications were found in the control group'

Moller, 2003

'No treatment associated adverse events were observed in the surfactant group; however, the expected risk of intermittent obstruction of the endotracheal tube with a short time deterioration on oxygenation was observed in 3 patients'

Not reported

Willson, 2005

Hypotension 9%

Hypotension 1%

Transient hypoxia 12%

Transient hypoxia 3%

Air leaks 13%

Air leaks 16%

Nosocomial pneumonia 6%

Nosocomial pneumonia 11%