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Table 1 Trial methodological quality

From: Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis

Trial Allocation concealment reported? (Method used) Who was reported to be blinded? (Who administered the intervention?) Completeness of follow-up reported?a Groups similar at baseline?b Ventilation algorithm described? Criteria for rescue therapyc
Luchetti, 1998 Yes (sealed envelopes) Not reported Not reported Yes Yes Not reported
Willson, 1999 Yes (opaque sealed envelopes) Unblinded 91% Lower PRISM scores in control group (9 versus 12) Yes No
Tibby, 2000 Not reported Care providers (investigators not involved in patient care) Not reported Yes Yes Not reported
Luchetti, 2002 Yes (sealed envelope) Outcome assessors (investigators) Not reported Yes Yes No
Moller, 2003 Yes (central telephone) Unblinded 87% Yes Yes Yes
Willson, 2005 Yes (opaque sealed envelopes) Care providers, investigators (respiratory therapist not involved in patient care) 100% More immunosuppressed in control group (30 versus 22) Yes No
  1. aPatients randomized but not included in the analysis. bPotentially clinically significant differences in age, aetiology, severity of illness (Pediatric Risk of Mortality (PRISM) score) and immunosuppression. cA priori criteria for the use of extracorporeal membrane oxygenation, high-frequency oscillatory ventilation, nitric oxide and open-label surfactant.