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Table 2 Baseline demographic and clinical characteristics of the GenIMS cohort

From: Use of dynamic microsimulation to predict disease progression in patients with pneumonia-related sepsis

Characteristic

Full GenIMS cohort

(n = 2,320)

Simulation model cohort

(n = 1,888)a

Age (years; mean ± SD)

65.6 ± 18.1

67.77 ± 16.80

Sex (% female)

47.70

47.98

Race (Caucasian/black [%])

79.20/16.30

80.72/15.73

Etiology (n [%])

  

   Bacterial pneumonia

  

Gram positive only

251 (10.80)

237 (12.55)

Gram negative only

58 (2.50)

54 (2.86)

Mixed Gram positive and negative

22 (1.00)

21 (1.11)

   Chlamydia or Legionella cultures

6 (0.30)

6 (0.32)

   Other

38 (1.60)

37 (1.96)

   Unknown

1,945 (83.80)

1,533 (81.20)

Charlson score (mean ± SD [% score = 0])

1.78 ± 2.16 (31.64)

1.93 ± 2.21 (27.54)

Admitted to hospital (n [%])

2,029 (87.50)

1,888 (100)

Admitted to hospital and pneumonia confirmed (n [%])

1,895 (81.70)

1,888 (100)

LOS (days; mean ± SD [median])

6.55 ± 5.10 (5)

7.26 ± 5.02 (6)

Admitted to ICU (%)

14.70

15.94

LOS in ICU (days; mean ± SD [median])

5.37 ± 5.04 (4)

5.53 ± 5.22 (4)

APACHE score day 1 (mean ± SD)

53.07 ± 20.30

56.23 ± 17.90

PSI time 0 (mean ± SD)

83.25 ± 34.25

73.53 ± 43.68

   PSI I and II (≤70; %)

37.70

42.74

   PSI III (71 to 90; %)

22.37

20.55

   PSI IV (91 to 130; %)

30.14

27.60

   PSI V (>130; %)

9.79

9.11

PSI day 1 (mean ± SD)

95.11 ± 40.41

100.16 ± 38.06

   PSI I and II (≤70; %)

29.01

22.14

   PSI III (71 to 90; %)

19.18

20.87

   PSI IV (91 to 130; %)

33.79

37.34

   PSI V (>130; %)

18.02

19.65

SOFA score day 1 (mean ± SD [% score = 0])

2.3 ± 1.92 (10.78)

2.33 ± 1.91 (12.50)

CNS organ failure, defined by the SOFA score (%)

5.22

5.93

Respiratory organ failure, defined by the SOFA score (%)

15.73

17.32

Liver organ failure, defined by the SOFA score (%)

0.52

0.64

Renal organ failure, defined by the SOFA score (%)

15.39

17.43

Circulatory organ failure, defined by the SOFA score (%)

3.58

3.97

Coagulation organ failure, defined by the SOFA score (%)

1.21

1.22

Discharged alive (%)

95.86

94.65

Severe sepsis subset mortality by day 90 (%)

25.51

26.91

   In-hospital (%)

25.43

26.64

Mortality (%)

  

   30 day

6.12

6.46

   60 day

8.35

9.16

   90 day

10.36

11.28

  1. aSee section on demographic and clinical characteristics for explanation of patient exclusions from overall GenIMS database. APACHE, Acute Physiology Age and Chronic Health Evaluation; CNS, central nervous system; ICU, intensive care unit; LOS, length of stay; PSI, Pneumonia Severity Index; SD, standard deviation;