Characteristic | Full GenIMS cohort (n = 2,320) | Simulation model cohort (n = 1,888)a |
---|---|---|
Age (years; mean ± SD) | 65.6 ± 18.1 | 67.77 ± 16.80 |
Sex (% female) | 47.70 | 47.98 |
Race (Caucasian/black [%]) | 79.20/16.30 | 80.72/15.73 |
Etiology (n [%]) | ||
Bacterial pneumonia | ||
Gram positive only | 251 (10.80) | 237 (12.55) |
Gram negative only | 58 (2.50) | 54 (2.86) |
Mixed Gram positive and negative | 22 (1.00) | 21 (1.11) |
Chlamydia or Legionella cultures | 6 (0.30) | 6 (0.32) |
Other | 38 (1.60) | 37 (1.96) |
Unknown | 1,945 (83.80) | 1,533 (81.20) |
Charlson score (mean ± SD [% score = 0]) | 1.78 ± 2.16 (31.64) | 1.93 ± 2.21 (27.54) |
Admitted to hospital (n [%]) | 2,029 (87.50) | 1,888 (100) |
Admitted to hospital and pneumonia confirmed (n [%]) | 1,895 (81.70) | 1,888 (100) |
LOS (days; mean ± SD [median]) | 6.55 ± 5.10 (5) | 7.26 ± 5.02 (6) |
Admitted to ICU (%) | 14.70 | 15.94 |
LOS in ICU (days; mean ± SD [median]) | 5.37 ± 5.04 (4) | 5.53 ± 5.22 (4) |
APACHE score day 1 (mean ± SD) | 53.07 ± 20.30 | 56.23 ± 17.90 |
PSI time 0 (mean ± SD) | 83.25 ± 34.25 | 73.53 ± 43.68 |
PSI I and II (≤70; %) | 37.70 | 42.74 |
PSI III (71 to 90; %) | 22.37 | 20.55 |
PSI IV (91 to 130; %) | 30.14 | 27.60 |
PSI V (>130; %) | 9.79 | 9.11 |
PSI day 1 (mean ± SD) | 95.11 ± 40.41 | 100.16 ± 38.06 |
PSI I and II (≤70; %) | 29.01 | 22.14 |
PSI III (71 to 90; %) | 19.18 | 20.87 |
PSI IV (91 to 130; %) | 33.79 | 37.34 |
PSI V (>130; %) | 18.02 | 19.65 |
SOFA score day 1 (mean ± SD [% score = 0]) | 2.3 ± 1.92 (10.78) | 2.33 ± 1.91 (12.50) |
CNS organ failure, defined by the SOFA score (%) | 5.22 | 5.93 |
Respiratory organ failure, defined by the SOFA score (%) | 15.73 | 17.32 |
Liver organ failure, defined by the SOFA score (%) | 0.52 | 0.64 |
Renal organ failure, defined by the SOFA score (%) | 15.39 | 17.43 |
Circulatory organ failure, defined by the SOFA score (%) | 3.58 | 3.97 |
Coagulation organ failure, defined by the SOFA score (%) | 1.21 | 1.22 |
Discharged alive (%) | 95.86 | 94.65 |
Severe sepsis subset mortality by day 90 (%) | 25.51 | 26.91 |
In-hospital (%) | 25.43 | 26.64 |
Mortality (%) | ||
30 day | 6.12 | 6.46 |
60 day | 8.35 | 9.16 |
90 day | 10.36 | 11.28 |