| Baseline | 15 minutes | 30 minutes | 45 minutes | 60 minutes | 75 minutes | 90 minutes |
---|---|---|---|---|---|---|---|
Control group | Â | Â | Â | Â | Â | Â | Â |
Mean arterial pressure (mmHg) | 102 ± 17 | 111 ± 10 | 123 ± 7 | 138 ± 0 | 143 ± 8 | 124 ± 10 | 105 ± 20 |
pH | 7.32 ± 0.05 | 7.32 ± 0.10 | 7.30 ± 0.10 | 7.26 ± 0.01 | 7.26 ± 0.02 | 7.26 ± 0.05 | 7.26 ± 0.02 |
PCO2 (mmHg) | 28 ± 9 | 40 ± 1 | 36 ± 0 | 37 ± 4 | 34 ± 5 | 29 ± 2 | 23 ± 5 |
PO2 (mmHg) | 241 ± 81 | 316 ± 18 | 325 ± 36 | 298 ± 16 | 331 ± 37 | 334 ± 10 | 340 ± 12 |
Tidal volume (ml/kg) | 15.0 ± 5.9 | 7.8 ± 1.3 | 7.8 ± 1.3 | 7.8 ± 1.3 | 6.9 ± 1.6 | 7.9 ± 1.4 | 9.9 ± 1.8 |
Peak pressure (cmH2O) | 16 ± 0 | 15 ± 1 | 16 ± 0 | 16 ± 0 | 16 ± 0 | 16 ± 0 | 16 ± 0 |
Intravenous fluid (ml) |  | 9.3 ± 0.7 |  |  |  |  |  |
High pressure/low PEEP group | Â | Â | Â | Â | Â | Â | Â |
Mean arterial pressure (mmHg) | 92 ± 13 | 79 ± 10 | 89 ± 10 | 86 ± 9* | 71 ± 11* | 64 ± 11* | 55 ± 10# |
pH | 7.25 ± 0.06 | 7.39 ± 0.05# | 7.37 ± 0.04# | 7.33 ± 0.03 | 7.31 ± 0.04 | 7.24 ± 0.04 | 7.20 ± 0.03 |
PCO2 (mmHg) | 30 ± 6 | 23 ± 5*†| 22 ± 4 | 21 ± 4 | 17 ± 3* | 16 ± 3 | 15 ± 4 |
PO2 (mmHg) | 187 ± 32 | 241 ± 37 | 260 ± 42 | 240 ± 54 | 244 ± 59 | 251 ± 54 | 232 ± 45 |
Tidal volume (ml/kg) | 12.2 ± 5.9 | 31.4 ± 5.5*#†| 30.3 ± 3.9*#†| 27.7 ± 2.6*#†| 38.4 ± 10.8*#†| 40.0 ± 13.2#†| 39.0 ± 9.2*#†|
Peak pressure (cmH2O) | 17 ± 0* | 39 ± 4* | 45 ± 1* | 45 ± 1* | 45 ± 1* | 45 ± 1* | 46 ± 2* |
Intravenous fluid (ml) |  | 12.6 ± 2.9 |  |  |  |  |  |
High pressure/high PEEP group | Â | Â | Â | Â | Â | Â | Â |
Mean arterial pressure (mmHg) | 105 ± 23 | 94 ± 13 | 100 ± 16 | 85 ± 14* | 84 ± 20* | 83 ± 16 | 66 ± 14 |
pH | 7.40 ± 0.05 | 7.27 ± 0.04 | 7.32 ± 0.08 | 7.28 ± 0.03 | 7.27 ± 0.04 | 7.23 ± 0.06# | 7.22 ± 0.09# |
PCO2 (mmHg) | 32 ± 3 | 44 ± 3 | 33 ± 7 | 26 ± 4 | 25 ± 3 | 19 ± 1 | 15 ± 1# |
PO2 (mmHg) | 263 ± 32 | 262 ± 40 | 315 ± 14 | 307 ± 27 | 317 ± 20 | 315 ± 11 | 317 ± 17 |
Tidal volume (ml/kg) | 12.9 ± 1.4 | 8.6 ± 2.4# | 9.6 ± 2.5# | 9.6 ± 2.6# | 9.6 ± 2.6# | 9.2 ± 2.4# | 9.2 ± 2.4# |
Peak pressure (cmH2O) | 17 ± 0* | 50 ± 3* | 50 ± 6* | 50 ± 3* | 50 ± 3* | 50 ± 3* | 50 ± 6* |
Intravenous fluid (ml) |  | 9.0 ± 1.9 |  |  |  |  |  |