Variable | No ARDS (n = 4,484) | ARDS (n = 246) | P value | Unadjusted odds ratio | ||
---|---|---|---|---|---|---|
Age in years, mean (SD) | 60.3 | (18.3) | 56.3 | (17.3) | 0.0008 | 0.988 |
Men, number (percentage) | 2,468 | (55.1) | 135 | (54.9) | 0.9543 | 0.993 |
Admitting diagnosisa, number (percentage) | Â | Â | Â | Â | Â | Â |
   Trauma | 578 | (12.9) | 41 | (16.7) | 0.0873 | 1.352 |
   Neurological | 760 | (17.0) | 25 | (10.2) | 0.0053 | 0.554 |
   Pneumonia | 630 | (14.1) | 58 | (23.6) | < 0.0001 | 1.887 |
   Sepsis/Systemic inflammatory response syndrome | 507 | (11.3) | 40 | (16.3) | 0.0180 | 1.523 |
   Post-operative | 892 | (19.9) | 61 | (24.8) | 0.0619 | 1.328 |
   Other | 1,741 | (38.8) | 64 | (26.0) | < 0.0001 | 0.554 |
ICU type, number (percentage) | Â | Â | Â | Â | Â | Â |
   Medical ICU | 1,591 | (35.5) | 74 | (30.1) | 0.0842 | 0.782 |
   Surgical ICU | 961 | (21.4) | 81 | (32.9) | < 0.0001 | 1.800 |
   Combined | 1,932 | (43.1) | 91 | (37.0) | 0.0599 | 0.776 |
Nutrition at baseline or ICU day 3–4a, number (percentage) |  |  |  |  |  |  |
   Enteral nutrition | 1,424 | (31.8) | 116 | (47.2) | < 0.0001 | 1.917 |
   Total parental nutrition | 474 | (10.6) | 67 | (27.2) | < 0.0001 | 3.167 |
   No nutrition or none recorded | 2,617 | (58.4) | 67 | (27.4) | < 0.0001 | 0.267 |
Process of care, number (percentage) | Â | Â | Â | Â | Â | Â |
   Antibiotics at baseline | 907 | (20.2) | 27 | (11.0) | 0.0004 | 0.486 |
   H2 antagonist at baseline | 519 | (11.6) | 7 | (2.8) | < 0.0001 | 0.224 |
   Continuous sedation | 80 | (1.8) | 10 | (4.1) | 0.0108 | 2.335 |
   Antibiotics and H2 antagonist | 1,307 | (29.1) | 44 | (17.9) | 0.0001 | 0.529 |
   Antibiotics and continuous sedation | 319 | (7.1) | 31 | (12.6) | 0.0014 | 1.883 |
   H2 antagonist and continuous sedation | 183 | (4.1) | 15 | (6.1) | 0.1242 | 1.526 |
   Antibiotics, H2 antagonist, and sedation | 675 | (15.1) | 111 | (45.1) | < 0.0001 | 4.640 |
   No process of care | 494 | (11.0) | 1 | (0.4) | < 0.0001 | 0.033 |
Severity of illness, mean (SD) | Â | Â | Â | Â | Â | Â |
   Baseline APACHE II score | 19.4 | (8.1) | 23.5 | (7.8) | < 0.0001 | 1.061 |
   SOFA score indicator | 6.6 | (3.9) | 9.0 | (3.8) | < 0.0001 | 1.154 |
Laboratory data at baseline | Â | Â | Â | Â | Â | Â |
   Serum creatinine > 2.0 mg/dl, number (percentage) | 782 | (17.6) | 57 | (23.2) | 0.0250 | 1.417 |
   Albumin ≤ 2.3 g/dl, number (percentage) | 1,086 | (29.8) | 115 | (54.0) | < 0.0001 | 2.763 |
   Hemoglobin in g/dl, mean (SD) | 10.8 | (2.5) | 10.3 | (2.4) | 0.0008 | 0.914 |
Transfusion | Â | Â | Â | Â | Â | Â |
   Any transfusion, number (percentage) | 1,892 | (42.2) | 164 | (66.7) | < 0.0001 | 2.737 |
   Units transfused, mean (SD) | 1.8 | (3.5) | 3.8 | (5.6) | < 0.0001 | 1.088 |