Table 4 Predictors of a low adrenocortictrophic hormone response in multivariate analysis
Factor | Increase <250 nmol/l | Peak <500 nmol/l | ||||
|---|---|---|---|---|---|---|
OR (95% CI) | P | Validity | OR (95% CI) | P | ||
Model 1a ( n = 404) | Model 1b ( n = 403) | |||||
Positive other local culture | na | 2.40 (1.32–4.37) | 0.004 | <5% | ||
Sepsis at admission | 2.34 (1.13–4.84) | 0.022 | <5% | na | ||
SOFA test day | 1.11 (1.03–1.18) | 0.003 | 50–80% | 1.11 (1.01–1.21) | 0.024 | 50–80% |
Baseline cortisol (nmol/l) | 1.001 (1.000–1.002) | 0.045 | 50–80% | 0.987 (0.985–0.990) | <0.0001 | >95% |
Platelets (× 109/l) | 0.998 (0.996–1.000) | 0.031 | 50–80% | 0.997 (0.994–1.000) | 0.044 | 50–80% |
Bicarbonate (mmol/l) | na | 0.91 (0.86–0.97) | 0.003 | 80–90% | ||
Cardiac surgery | 0.48 (0.26–0.86) | 0.013 | 90–95% | na | ||
Arterial pH | 0.011 (0.001–0.185) | 0.002 | >95% | na | ||
Model 2a ( n = 330) | Model 2b ( n = 332) | |||||
SOFA test day | na | 1.19 (1.09–1.30) | <0.0001 | 90–95% | ||
Heart rate (beats/min) | 1.015 (1.003–1.028) | 0.015 | 50–80% | na | ||
Platelets (× 109/l) | 0.997 (0.995–0.999) | 0.009 | 50–80% | na | ||
Baseline cortisol (nmol/l) | na | 0.986 (0.983–0.990) | <0.0001 | >95% | ||
Albumin (g/l) | 0.93 (0.90–0.97) | 0.001 | 90–95% | 0.92 (0.87–0.97) | 0.003 | 80–90% |
Cardiac surgery | 0.40 (0.20–0.79) | 0.008 | >95% | na | ||
Arterial pH | 0.002 (0.0001–0.048) | <0.0001 | >95% | na | ||