Table 3 Predictors of a low response to adrenocorticotrophic hormone

Time from admission (days)^a

5 (1–77)

3 (1–92)

<0.0001

4 (1–77)

4 (1–92)

Intubation^a

161 (95)

229 (97)

261 (95)

129 (100)

0.004

na

   Time until test (days)^a

4 (0–76)

2 (0–70)

0.001

3 (0–76)

3 (0–70)

Fluconazole^a

12 (7)

29 (12)

0.077

1.85

(0.92–3.75)

22 (8)

19 (15)

0.050

2.00

(1.04–3.83)

   Time until test (days)

4 (0–15)

7 (0–63)

0.038

6 (0–63)

5 (0–53)

SAPS II*

35 (7–97)

44 (7–100)

<0.0001

39 (9–97)

40 (7–100)

SOFA*

8 (0–21)

10 (0–21)

<0.0001

8 (0–21)

10 (0–21)

0.014

Multiple organ dysfunction^a

103 (61)

194 (83)

<0.0001

3.08

(1.95–4.86)

192 (70)

105 (81)

0.016

1.92

(1.15–3.19)

Heart rate (beats/min)^a

90 (48–146)

96 (59–171)

0.001

94 (48–171)

94 (52–146)

Vasopressors/inotropes^a

134 (79)

206 (88)

0.020

1.91

(1.12–3.26)

226 (82)

114 (88)

Mechanical ventilation^a

152 (89)

224 (95)

0.031

2.41

(1.11–5.25)

250 (91)

126 (98)

0.012

4.37

(1.30–14.71)

FiO₂^b

0.41 (0.29–1.0)

0.50 (0.34–1.0)

<0.0001

0.45 (0.29–1.0)

0.49 (0.30–1.0)

PaO₂/FiO₂^b

240 (59–681)

203 (44–641)

0.005

220 (44–681)

225 (77–641)

Renal replacement^a

23 (14)

47 (20)

35 (13)

35 (27)

0.001

2.56

(1.52–4.33)

Urine production (ml)^a

255 (0–8845)

1667 (0–6970)

<0.0001

1989 (0–10140)

1697 (0–6970)

Creatinine (μmol/l)^a

92 (23–695)

122 (20–1934)

<0.0001

112 (20–1934)

116 (36–675)

Urea (mmol/l)^b

10.2 (0.7–46.3)

13.3 (1.5–149)

0.018

12.1 (1.0–149)

12.4 (0.7–89.8)

Glasgow Coma Scale score^a

15 (3–15)

11 (3–15)

0.070

11 (3–15)

15 (3–15)

Positive other local culture^a

50 (29)

88 (37)

76 (28)

62 (48)

<0.0001

2.43

(1.58–3.76)

SIRS^a

116 (68)

194 (83)

0.001

2.20

(1.38–3.51)

213 (77)

97 (75)

Sepsis^a

80 (47)

138 (59)

0.021

1.60

(1.08–2.38)

147 (53)

71 (55)

Haemoglobin (mmol/l)^a

5.8 (4.0–7.9)

5.7 (3.6–9.7)

5.8 (4.0–8.8)

5.6 (3.6–9.7)

0.011

Haematocrit^a

0.28 (0.20–0.38)

0.27 (0.17–0.44)

0.28 (0.20–0.43)

0.26 (0.17–0.44)

0.004

Platelets (× 10⁹/l)^a

192 (20–818)

130 (3–756)

<0.0001

173 (4–818)

123 (3–468)

0.001

Eosinophils (%)

1 (0–5)

0 (0–4)

0.014

0 (0–5)

0 (0–1)

Albumin (g/l)^b

17 (6–32)

13 (3–34)

<0.0001

17 (3–34)

12 (3–32)

<0.0001

Bilirubin (μmol/l)^c

10 (3–176)

14 (2–441)

0.001

12 (2–280)

12 (2–441)

Arterial pH^a

7.43 (7.07–7.56)

7.38 (6.89–7.64)

<0.0001

7.41 (6.89–7.64)

7.39 (7.02–7.54)

0.039

Bicarbonate (mmol/l)^a

25.0 (6.6–37.8)

21.7 (6.8–37.0)

<0.0001

23.8 (6.6–37.8)

21.9 (12.1–33.4)

0.005

Glucose (mmol/l)^a

7.6 (1.9–35.0)

7.1 (2.3–25.8)

0.036

7.3 (2.6–35.0)

7.1 (1.9–25.8)