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Table 5 Diagnostic efficiency values for serum creatinine, cystatin C, and beta2-microglobulin to detect early renal disfunction by Schwartz formula

From: Cystatin C and beta2-microglobulin: markers of glomerular filtration in critically ill children

 

Serum creatinine

Cystatin C

Beta2-microglobulin

Cutoff value

0.4 mg/dl

0.6 mg/l

1.5 mg/l

Sensitivity

44% (38%–50%)

88% (83%–94%)

100% (94%–100%)

Specificity

56% (52%–59%)

50% (46%–53%)

50% (46%–53%)

Positive likelihood ratio

1.0 (1.0–1.0)

1.7 (1.7–1.8)

2.0 (1.9–2.0)

  1. Sensitivity, specificity, and positive likelihood ratio (95% confidence interval) for serum creatinine, cystatin C, and beta2-microglobulin to diagnose renal dysfunction (creatinine clearance estimation by Schwartz formula less than 80 ml/minute per 1.73 m2) are shown.
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Critical Care

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