Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model

Table 1 Hemodynamics, hematology, and lactate measurements in sham and CLP mice

Group	Number	Mean arterial pressure (mm Hg)		Heart rate (beats per minute)		Hemoglobin^a (g/dl)	White blood cell count^a (10³/μl)	Platelets^a (10³/μl)	Lactate^a (mmol/l)
		0 minutes	40 minutes	0 minutes	40 minutes
Sham+NS	6	86 (1.9)^b	87 (2.4)	277 (8)	283 (13)	12.7 (0.5)	6.36 (0.84)	1,356.8 (81.3)	0.90 (0.17)
Sham+EPO	6	90 (4.7)	86 (4.3)	294 (11)	293 (4)	12.8 (0.8)	5.97 (1.26)	1,206.7 (128.6)	0.79 (0.18)
CLP+NS	7	73 (1.8)^c	68 (2.7)^c	337 (30)	358 (29)	12.1 (0.6)	1.19 (0.35)^c	938.8 (82.7)^d	1.94 (0.37)^d
CLP+EPO	7	70 (2.8)^c	71 (3.0)^d	328 (26)	340 (25)	12.7 (0.6)	1.09 (0.29)^c	956.1 (55.2)	1.91 (0.26)^c

^aBlood sample obtained at 40 minutes; ^bmean (± standard error); ^cp < 0.01 versus corresponding control groups; ^dp < 0.05 versus corresponding control groups. CLP, cecal ligation and perforation; EPO, erythropoietin; NS, normal saline.

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