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Table 1 Baseline and day 3 characteristics of patients in the derivation cohort

From: Prediction of death and prolonged mechanical ventilation in acute lung injury

Characteristic Alive and not ventilator dependent by day 15 Dead, ventilator-dependent, or with tracheostomy by day 15 P
Age 53 (40 to 66) 63 (49 to 72) 0.004
Female sex (n [%]) 34 (46) 87 (34) 0.063
BMI (kg/m2) 27 (24 to 31) 26 (23 to 31) 0.138
SAPS II score 46 (37 to 58) 47 (35 to 59) 0.760
Sepsis (n [%]) 28 (38%) 99 (39%) 0.897
Extrapulmonary cause of ALI/ARDS (n [%]) 29 (27%) 45 (20%) 0.205
Day 3 PaCO2 (mmHg) 39 (33 to 44) 41 (36 to 47) 0.012
Day 3 PaO2/FiO2 174 (146 to 195) 153 (105 to 198) 0.013
Day 3 Vt (ml/kg PBW) 9.1 (7.2 to 10.6) 8.5 (7.1 to 10.4) 0.181
Day 3 Ppl (cmH2O) 23 (19 to 26) 26 (21 to 30) 0.012
Day 3 Ppk (cmH2O) 28 (26 to 32) 31 (27 to 38) 0.010
Day 3 PEEP (cmH2O) 5 (5 to 9) 8 (5 to 12) 0.003
Day 3 VE40 (ml/kg PBW/min) 142 (109 to 186) 162 (128 to 214) 0.006
Day 3 oxygenation index 10.4 (8.2 to 14.7) 13.9 (9.3 to 23.1) 0.001
Day 3 ΔPEEP (cmH2O)a 0 (-2 to 0) 0 (0 to 3) < 0.001
Day 3 SOFA score 9 (7 to 10) 10 (7 to 13) 0.055
Day 3 shock (n [%]) 14 (19) 99 (39) 0.001
  1. The values are presented as median (interquartile range) for continuous variables and number (%) for categorical variables. ALI, acute lung injury/acute respiratory distress syndrome; BMI, body mass index; FiO2, fractional inspired oxygen; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; PBW, predicted body weight; PEEP, positive end-expiratory pressure; Ppk, peak airway pressure; Ppl, plateau airway pressure; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment, VE40, minute ventilation required to achieve PaCO2 of 40 mmHg; Vt, tidal volume. aPEEP at day 3 minus PEEP at day 1.