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Table 3 Time course of renal functional variables and alpha-1-microglobuline excretion

From: The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting

  

t0

t2

t6

t10

t14

UV (milliliters per minute)

ADR

3.3 ± 1.3b

2.7 ± 1.3

1.7 ± 0.7a

1.6 ± 0.7a

1.3 ± 0.5a

 

MIL

3.2 ± 1.9b

3.5 ± 2.8

2.1 ± 0.8a

1.5 ± 0.4a

1.4 ± 0.6a

 

CON

5.6 ± 2.6

4.8 ± 2.3

2.5 ± 0.9a

1.9 ± 0.6a

1.6 ± 0.6a

CCrea (milliliters per minute)

ADR

82.1 ± 30.5

76.0 ± 16.5

111.7 ± 59.5

120.6 ± 61.5

121.2 ± 62.2

 

MIL

132.1 ± 55.6

149.7 ± 87.8

119.2 ± 36.5

119.3 ± 40.4

116.4 ± 58.6

 

CON

135 ± 62.5

134.7 ± 51.8

150.6 ± 53.9

152.7 ± 37.0

136.3 ± 51.0

FENa (percentage)

ADR

4.0 ± 2.2

2.8 ± 1.8

1.3 ± 1.3a

1.6 ± 1.3a

1.4 ± 0.7a

 

MIL

2.2 ± 1.1

2.4 ± 2.6

1.5 ± 1.1

0.9 ± 0.8a

1.0 ± 0.7a

 

CON

2.9 ± 2.4

2.5 ± 1.9

1.5 ± 0.6a

1.1 ± 0.5a

1.3 ± 0.6a

A1-MGU (milligrams per mole of creatinine)

ADR

225 ± 118

292 ± 133bc

200 ± 85ab

154 ± 63ab

135 ± 60ab

 

MIL

206 ± 73

186 ± 75

156 ± 67a

117 ± 51ab

105 ± 46a

 

CON

208 ± 64

170 ± 67a

110 ± 48a

71 ± 28

72 ± 50a

  1. The time course of renal function parameters (urine flow [UV], creatinine clearance [CCrea], fractional excretion of sodium [FENa], and the urinary excretion of alpha-1-microglobuline [A1-MGU]) in patients who presented with myocardial dysfunction (cardiac index of less than 2.2 liters/minute per square meter despite optimization of mean arterial pressure and filling pressures) upon intensive care unit admission and who were treated with adrenaline (ADR) or milrinone (MIL) and of control patients (CON) not needing inotropic after coronary artery bypass grafting with cardiopulmonary bypass. aSignificant difference (p < 0.05) in comparison with baseline (t0); bsignificant difference (p < 0.05) in comparison with the control group; csignificant difference (p < 0.05) between the adrenaline and the milrinone group.