Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review

Table 1 Characteristics of included studies: parallel-design studies

Study	Year	Country of origin	Randomization	Conventional therapy				PMX-F
				N	Percentage of males	APACHE II score	Predicted mortality (percentage)	N	Percentage of males	APACHE II score	Predicted mortality (percentage)
Tani et al. [21] (a)^a	1998	Japan	No	33	69.7	SSS 39.1	N/A	37	78.4	SSS 46.2	N/A
Nakamura et al. [10]	1999	Japan	Yes	20	60.0	NS	N/A	30	60.0	24.8	52.6
Nemoto et al. [14]	2001	Japan	Yes	44	61.4	23	46.0	54	64.7	22	42.4
Nakamura et al. [11] (a)	2002	Japan	Yes	9	66.7	27.5	62.2	9	66.7	28.5	65.6
Suzuki et al. [15]	2002	Japan	Yes	24	70.8	25	53.3	24	75.0	25	53.3
Tsushima et al. [33]	2002	Japan	No	10	80.0	NS	N/A	24	70.8	22.4	43.9
Tsugawa et al. [31]	2002	Japan	No	51	43.1	NS	N/A	31	45.2	NS	N/A
Nakamura et al. [8] (b)	2003	Japan	Yes	10	60.0	27	60.5	10	60.0	27.6	62.5
Nakamura et al. [12] (c)	2003	Japan	Yes	25	64.0	23	46.4	35	68.6	24.2	50.4
Nakamura et al. [29] (d)	2003	Japan	No	108	62.0	24	49.7	206	64.1	24.6	51.9
Nakamura et al. [13] (e)	2004	Japan	Yes	10	60.0	28	63.9	15	60.0	28.4	65.2
Nakamura et al. [9] (f)	2004	Japan	Yes	50	64.0	24.8	52.6	70	61.4	25.4	54.8
Ono et al. [30]	2004	Japan	No	13	61.5	8.8	9.7	10	60.0	19.6	34.2
Tsujimoto et al. [32]	2004	Japan	No	10	20.0	10.6	12.2	7	85.7	19.4	33.5
Nakamura et al. [19] (g)	2005	Japan	No	12	58.3	25	53.3	14	64.3	25.5	55.1
Vincent et al. [28]	2005	Belgium, UK, Germany, Netherlands, Spain	Yes	18	47.4	18.7	31.3	17	76.5	16.7	25.4
Total				447				593

^aTwo studies reported severity of illness as SSS rather than APACHE score.
APACHE II score expressed as the mean. Predicted mortality was calculated as e^Logit/(1+ e^Logit), where Logit = -3.517 + (APACHE II) × 0.146. APACHE, Acute Physiology and Chronic Health Evaluation; N/A, not applicable; NS, not stated; PMX-F, polymyxin B-immobilized fiber column; SSS, Sepsis Severity Score.

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