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Table 4 Comparison of cortisol and cytokine levels in CSF between bacterial and aseptic meningitis and controls

From: Cortisol levels in cerebrospinal fluid correlate with severity and bacterial origin of meningitis

Parameter in CSF

Bacterial meningitis patients (n = 47)

Aseptic meningitis patients (n = 37)

Control individuals (n = 13)

P a

TNF-α (pg/ml)

245 (20–4,978)

< 20

< 20

0.001

IL-1β (pg/ml)

254 (20–1,239)

N/A

< 20

N/A

IL-6 (pg/ml)

187,245 (75,275–312,289)

157 (38–410)

< 20

0.001

IL-8 (pg/ml)

16,830 (4,776–133,236)

130 (54–321)

< 20

0.001

IL-10 (pg/ml)

260 (20–1,153)

71 (61–116)

< 20

0.001

Cortisol (nmol/l)

133 (59–278)

17 (13–28)

10 (8–12)

0.001

  1. Data are presented as median (interquartile range). aBacterial meningitis versus aseptic meningitis (Mann-Whitney U-test). CSF, cerebrospinal fluid; ICU, intensive care unit; IL, interleukin; N/A, not available; TNF, tumour necrosis factor.