High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study

Table 3 Levels of HMGB1, PCT, LBP, CRP, IL-6, WBC, and neutrophils in different groups

Variable	Healthy controls (n = 32)	Non-infected patients (n = 67)	Infected patients without SIRS (n = 32)	Patients with sepsis (n = 47)	Patients with severe sepsis (n = 27)	P value^a
HMGB1 (ng/ml)						< 0.001
Median	0.77	1.54	2.41	2.24	2.18
IQR	0.6–1.46	0.79–2.88	0.63–3.44	1.30–3.75	0.91–3.85
PCT (ng/ml)						< 0.001
Median		0.09	0.16	0.2	1.9
IQR		0.05–0.13	0.07–0.34	0.08–0.65	0.22–14.6
LBP (μg/ml)						< 0.001
Median		16.3	27.4	33.5	40.4
IQR		12.05–25.3	18.3–41.2	25.0–43.2	18.0–63.6
CRP (mg/l)						< 0.001
Median		18	122.0	120.0	217.0
IQR		10–42	54.0–215.0	41.0–190.0	78.0–414.0
IL-6 (pg/ml)						< 0.001
Median		9.8	20.6	72.6	199.3
IQR		2.85–21.65	9.8–99.4	25.9–274.5	67.5–2,833.0
WBC count (10⁹/l)						< 0.001
Median		8.2	9.5	13.0	12.2
IQR		6.7–10.3	7.7–11.9	9.2–17.1	7.0–17.5
Neutrophils (10⁹/l)						< 0.001
Median		6.19	7.1	10.1	10.3
IQR		4.73–7.9	5.1–9.7	7.1–14.8	5.5–15.4
sCD163 (mg/l)						0.06
Median		2.99	3.62	3.17	3.63
IQR		2.21–4.05	2.44–4.54	2.27–4.64	2.67–5.72

^aKruskal-Wallis test. CRP, C-reactive protein; HMGB1, high mobility group box-1 protein; IL-6, interleukin-6; IQR, interquartile range; LBP, lipopolysaccharide-binding protein; PCT, procalcitonin; sCD163; soluble haemoglobin scavenger receptor; SIRS, systemic inflammatory response syndrome; WBC, white blood cell.

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