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Figure 4 | Critical Care

Figure 4

From: Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment

Figure 4

Effects of hyperoxia on stretch-induced JNK activation of airway epithelium in JNK knockout mice. Representative photomicrographs (×400) with phospho-JNK staining of the lung sections after five hours of mechanical ventilation with room air or hyperoxia (n = 5 per group). (a) Control wild-type mice with room air. (b) Control wild-type mice with hyperoxia. (c) Wild-type mice ventilated at a tidal volume (VT) of 30 ml/kg with room air. (d) Wild-type mice ventilated at a VT of 30 ml/kg with hyperoxia. (e) JNK1-/- mice ventilated at a VT of 30 ml/kg with room air. (f) JNK1-/- mice ventilated at a VT of 30 ml/kg with hyperoxia. Positive staining of airway epithelia is identified by arrows. A dark brown DAB signal indicates positive staining for JNK in the lung epithelium, and shades of bluish tan signify non-reactive cells. DAB, diaminobenzidine; JNK, c-Jun NH2-terminal kinase.

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Critical Care

ISSN: 1364-8535