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Figure 3 | Critical Care

Figure 3

From: Hyperoxia increases ventilator-induced lung injury via mitogen-activated protein kinases: a prospective, controlled animal experiment

Figure 3

Effects of hyperoxia on high-tidal volume (VT)-induced mitogen-activated protein kinase activation. (a) Phosphorylated JNK expression (top panel), total JNK protein expression (middle panel), and quantitation by arbitrary units (bottom panel) (n = 5 per group). (b) Phosphorylated p38 expression (top panel), total p38 protein expression (middle panel), and quantitation by arbitrary units (bottom panel) (n = 5 per group). (c) Phosphorylated ERK1/2 expression (top panel), total ERK1/2 protein expression (middle panel), and quantitation by arbitrary units (bottom panel) (n = 5 per group). The relative phosphorylation was expressed in arbitrary units. *p < 0.05 versus control, non-ventilated mice; †p < 0.05 versus all other groups. ERK, extracellular signal-regulated kinase; JNK, c-Jun NH2-terminal kinase; O2, mice with hyperoxia; RA, mice with room air; WT, wild-type C57BL/6 mice.

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