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Table 3 Liver serum markers

From: Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress

 

Group

Tbaseline

TALI

T6 h

T18 h

T24 h

AST, U/l

PCV

26 (24–30)

29 (27–32)a

50 (42–58)a,b

81 (69–155)a-c

150 (103–191)a-d

 

PCV+R

31 (25–38)

29 (28–37)

126 (64–231)a,b

138 (105–197)a,b

262 (230–364)a-e

ALT, U/l

PCV

31.2 (24.8–35.5)

28.1 (25.4–29.9)a

26 (25.1–28.7)a

25.6 (20.2–31.6)a

23.5 (20.1–30)a

 

PCV+R

39.3 (36–44.7)

36.3 (31.5–41)

37.6 (34.6–40.7)e

32.5 (30.5–36.8)

37.3 (33.8–37.8)

GGT, U/l

PCV

42.5 (37.6–43.2)

35.7 (32.9–38.6)a

37.6 (31.9–40.6)a

36.5 (31–38.4)a

34.3 (29.1–34.7)a

 

PCV+R

37.8 (34.3–42.7)

38.5 (30–41.6)

34.6 (28.4–38.2)a,b

33.6 (27.8–36.6)a,b

33.3 (27–35.6)a,b

LDH, U/l

PCV

544 (482–585)

498 (442–545)

550 (492–606)a,b

587 (565–814)a,b

647 (580–921)a,b

 

PCV+R

607 (437–716)

565 (474–799)

677 (645–1,039)a,b

1,012 (653–1,689)a-c

1,262 (872–2,082)a-e

AP, U/l

PCV

99 (71–122)

91 (64–123)a

92 (70–113)a

93 (65–106)a

84 (60–110)a-d

 

PCV+R

82 (79–94)

78 (76–89)

88 (82–98)

87 (82–93)

86 (78–90)

ChE, U/l

PCV

356 (339–471)

357 (307–422)

387 (315–433)

363 (323–403)

318 (297–417)

 

PCV+R

431 (359–461)

381 (353–437)a

413 (333–425)a

358 (339–429)a

368 (339–423)a

TotBili, μmol/l

PCV

3.4 (3.0–5.1)

1.7 (1.7–2.1)

2.6 (1.7–3.4)

3.4 (1.7–5.1)

3.4 (1.7–3.8)

 

PCV+R

4.3 (3.4–7.3)

3.4 (3.0–4.3)a

6.8 (6.0–9.0)a,b,e

6.8 (4.7–7.3)a,b

8.6 (6.4–9.4)a,b,e

DirBili, μmol/l

PCV

0.8 (0.5–0.9)

0.3 (0.2–0.5)

0.4 (0.3–0.7)

0.6 (0.3–1.0)

0.6 (0.3–1.0)

 

PCV+R

0.7 (0.5–0.9)

0.7 (0.5–1.1)e

1.4 (0.6–1.8)e

1.6 (1.3–1.8)e

2.2 (1.7–2.3)e

Lactate, mmol/l

PCV

4.2 (2.9–10.4)

1 (1–1.6)a

0.7 (0.7–0.9)a,b

0.7 (0.7–0.8)a,b

0.7 (0.5–0.9)a,b

 

PCV+R

4 (3.2–6.8)

0.9 (0.8–1.1)a

1.3 (1.2–2.1)a,b,e

0.9 (0.8–1)a,c

1 (0.9–1.2)a,c,e

  1. Data are presented as the median (interquartile range). a-dFriedman repeated measures analysis of variance on rank with all pairwise multiple comparison procedures (Student-Newman-Keuls method). aversus Tbaseline, bversus TALI, cversus T6 h, dversus T18 h (p < 0.05). eMann-Whitney rank sum test: p < 0.05 versus PCV. ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; ChE, cholinesterase; DirBili, direct bilirubin GGT, γ-glutamyltransferase; LDH, lactate dehydrogenase; PCV, pressure-controlled ventilation; PCV+R, pressure-controlled ventilation with recruitment manoeuvre; T6 h, time point 6 hours after randomisation; T18 h, time point 18 hours after randomisation; T24 h, time point 24 hours after randomisation; TALI, time point after lung injury; Tbaseline, baseline time point; TotBili, total bilirubin.