| Group | Tbaseline | TALI | T6 h | T18 h | T24 h |
---|---|---|---|---|---|---|
AST, U/l | PCV | 26 (24–30) | 29 (27–32)a | 50 (42–58)a,b | 81 (69–155)a-c | 150 (103–191)a-d |
 | PCV+R | 31 (25–38) | 29 (28–37) | 126 (64–231)a,b | 138 (105–197)a,b | 262 (230–364)a-e |
ALT, U/l | PCV | 31.2 (24.8–35.5) | 28.1 (25.4–29.9)a | 26 (25.1–28.7)a | 25.6 (20.2–31.6)a | 23.5 (20.1–30)a |
 | PCV+R | 39.3 (36–44.7) | 36.3 (31.5–41) | 37.6 (34.6–40.7)e | 32.5 (30.5–36.8) | 37.3 (33.8–37.8) |
GGT, U/l | PCV | 42.5 (37.6–43.2) | 35.7 (32.9–38.6)a | 37.6 (31.9–40.6)a | 36.5 (31–38.4)a | 34.3 (29.1–34.7)a |
 | PCV+R | 37.8 (34.3–42.7) | 38.5 (30–41.6) | 34.6 (28.4–38.2)a,b | 33.6 (27.8–36.6)a,b | 33.3 (27–35.6)a,b |
LDH, U/l | PCV | 544 (482–585) | 498 (442–545) | 550 (492–606)a,b | 587 (565–814)a,b | 647 (580–921)a,b |
 | PCV+R | 607 (437–716) | 565 (474–799) | 677 (645–1,039)a,b | 1,012 (653–1,689)a-c | 1,262 (872–2,082)a-e |
AP, U/l | PCV | 99 (71–122) | 91 (64–123)a | 92 (70–113)a | 93 (65–106)a | 84 (60–110)a-d |
 | PCV+R | 82 (79–94) | 78 (76–89) | 88 (82–98) | 87 (82–93) | 86 (78–90) |
ChE, U/l | PCV | 356 (339–471) | 357 (307–422) | 387 (315–433) | 363 (323–403) | 318 (297–417) |
 | PCV+R | 431 (359–461) | 381 (353–437)a | 413 (333–425)a | 358 (339–429)a | 368 (339–423)a |
TotBili, μmol/l | PCV | 3.4 (3.0–5.1) | 1.7 (1.7–2.1) | 2.6 (1.7–3.4) | 3.4 (1.7–5.1) | 3.4 (1.7–3.8) |
 | PCV+R | 4.3 (3.4–7.3) | 3.4 (3.0–4.3)a | 6.8 (6.0–9.0)a,b,e | 6.8 (4.7–7.3)a,b | 8.6 (6.4–9.4)a,b,e |
DirBili, μmol/l | PCV | 0.8 (0.5–0.9) | 0.3 (0.2–0.5) | 0.4 (0.3–0.7) | 0.6 (0.3–1.0) | 0.6 (0.3–1.0) |
 | PCV+R | 0.7 (0.5–0.9) | 0.7 (0.5–1.1)e | 1.4 (0.6–1.8)e | 1.6 (1.3–1.8)e | 2.2 (1.7–2.3)e |
Lactate, mmol/l | PCV | 4.2 (2.9–10.4) | 1 (1–1.6)a | 0.7 (0.7–0.9)a,b | 0.7 (0.7–0.8)a,b | 0.7 (0.5–0.9)a,b |
 | PCV+R | 4 (3.2–6.8) | 0.9 (0.8–1.1)a | 1.3 (1.2–2.1)a,b,e | 0.9 (0.8–1)a,c | 1 (0.9–1.2)a,c,e |