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Table 2 Parameters of the TK/TD relationships model regarding the naloxone infusion rate versus R,S- and R-methadone concentrations

From: Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

 

EC 50

γ

 

(ng/ml)

 

R-methadone

173

7.8

R,S-methadone

334

10.0

  1. γ, Hill coefficient; EC50, concentration associated with a half-maximum effect; E max , maximum effect; TK/TD, toxicokinetic/toxicodynamic.