Skip to main content

Table 1 Toxicokinetic parameters of the racemic R,S-methadone and both R- and S-methadone forms in a severely poisoned patient

From: Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships

 

T 1/2

Maximal observed concentration

AUC inf

V z /F

Cl t /F

 

(h)

(ng/ml)

(ng-h/ml)

(l)

(l/h)

R-methadone

16.1

566

13,241

211

9.1

S-methadone

13.2

637

13,385

170

9.0

R,S-methadone

14.5

1,204

26,508

189

9.1

  1. AUC inf , area under the curve from 0 to infinity; Cl t /F, total plasma clearance; T1/2, half-life; V z /F, distribution volume.