From: Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships
T 1/2
Maximal observed concentration
AUC inf
V z /F
Cl t /F
(h)
(ng/ml)
(ng-h/ml)
(l)
(l/h)
R-methadone
16.1
566
13,241
211
9.1
S-methadone
13.2
637
13,385
170
9.0
R,S-methadone
14.5
1,204
26,508
189