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Table 1 Definitions of coagulopathy in the recent trauma literature

From: Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials

Laboratory parameters Source
PT ≥1.5 N (0) 1.5–2 N (1) >2 N (2) Mayo et al., 2004 [11]
PTT ≥1.5 N (0) 1.5–2 N (1) >2 N (2)  
Plt >100 (0) 50–100 (1) ≥50 (2)  
Fib >100 (0) 50–100 (1) ≥50 (2)  
Total: 0 mild, 1–3 moderate, 4–8 severe  
INR >1.4 or Plt <100,000 or both Dutton et al., 2004 [9]
PT >18 seconds or PTT >60 seconds or TT >15 seconds Brohi et al., 2003 [6]
PT >14 seconds or PTT >34 seconds MacLeod et al., 2003 [7]
PT >15 seconds or PTT >45 seconds or Fib <100 Vaslef et al., 2002 [37]
PT or PTT twice normal Cosgriff et al., 1997 [10]
PT or PTT >1.5–1.8 times control values Stehling et al., 1996 [8]
Ongoing bleeding, oozing from cut surfaces, catheters, or mucous membranes Lynn et al., 2002 [31]
  1. Fib, fibrinogen; INR, international normalized ratio; N, normal; Plt, platelet; PT, prothrombin time; PTT, partial thromboplastin time; TT, thrombin time.