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Table 2 Comparison of hemostatic variables and oxygenation capacity before and after rFVIIa in patients with DAH

From: Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage

Timing

24 hours prior to rFVIIa

24 hours after rFVIIaa

Patient number

1

2

3

4

5

6

1b

2

3

4

5

6

Coagulation

Platelet count (109 per liter)

110

88

112

105

99

90

100

80

106

105

102

69

 

APTT (seconds)

31

36

32

33

41

27

33

38

32

33

38

27

Transfusion (units)

RBCs

4

3

2

4

3

4

1

0

0

4

1

2

 

FFP

4

2

2

2

2

2

0

0

0

2

0

0

 

PC

2

2

2

2

2

1

0

0

0

2

0

0

Oxygenation capacity

PaO2/FiO2 ratio (mm Hg)

67

62

88

64

187

100

176

152

132

313

213

345

  1. aThe increase in oxygenation capacity was significant (p = 0.024, Wilcoxon signed paired rank test). bThere was a steady increase in oxygenation capacity subsequent to rFVIIa therapy (that is, the PaO2/FiO2 ratio was 176 mm Hg after one day, 137 mm Hg after one month, 136 mm Hg after two months, and finally 252 mm Hg after three months). APTT, activated partial thromboplastin time; DAH, diffuse alveolar hemorrhage; FFP, fresh frozen plasma; PaO2/FiO2, arterial oxygen pressure/inspiratory fractional oxygen content; PC, platelet concentrate; RBC, red blood cell; rFVIIa, human recombinant activated factor VII.
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Critical Care

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