Perioperative course of prothrombin fragment 1 + 2 (F1+2), tissue factor pathway inhibitor (TFPI), thromboxane B2 (TxB2), and monocyte chemoattractant protein-1 (MCP-1). (a) Time course of F1+2 in both patient groups. F1+2 concentrations increased after heparin, reaching a maximum value at the end of cardiopulmonary bypass (CPB). Postoperatively, F1+2 concentrations showed baseline values. (b) Time course of TFPI in both patient groups. TFPI levels increased after heparin administration and decreased from the end of CPB on to reach baseline values. **p < 0.01 comparing both patient groups. (c) Time course of TxB2 in both patient groups. TxB2 values decreased at the beginning of CPB and reached maximum values at the end of CPB. In the postoperative course, TxB2 levels were found to be similar to preoperative values. *p < 0.05 comparing both patient groups. (d) Time course of MCP-1 in both patient groups. MCP-1 concentrations increased during CPB to reach preoperative values five minutes after protamine administration. TCPC, total cavopulmonary connection.