Figure 2From: Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injuryProposed schema for APC signaling in the endothelial cell. APC binds to EPCR, which then interacts with the S1P1 receptor leading to its phosphorylation by PI3-kinase. S1P1 signaling through Rac1 leads to cortical cytoskeletal rearrangement and endothelial barrier protection. APC, activated protein C; EPCR, epithelial protein C receptor; PI3-kinase, phosphatidyl-inositol-3 kinase; S1P, sphingosine 1-phosphate. Reprinted with permission from the American Society for Biochemistry and Molecular Biology [28].Back to article page