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Figure 2 | Critical Care

Figure 2

From: Bench-to-bedside review: The role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury

Figure 2

Proposed schema for APC signaling in the endothelial cell. APC binds to EPCR, which then interacts with the S1P1 receptor leading to its phosphorylation by PI3-kinase. S1P1 signaling through Rac1 leads to cortical cytoskeletal rearrangement and endothelial barrier protection. APC, activated protein C; EPCR, epithelial protein C receptor; PI3-kinase, phosphatidyl-inositol-3 kinase; S1P, sphingosine 1-phosphate. Reprinted with permission from the American Society for Biochemistry and Molecular Biology [28].

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