Table 1 Studies evaluating the use of high-frequency oscillatory ventilation in adult patients with acute respiratory distress syndrome
Author, year | Study design | n | Baseline characteristics | Mean CV prior to HFOV (days) | Mortality | Death due to respiratory failure (%) | Selected complications |
|---|---|---|---|---|---|---|---|
Fort and colleagues, 1997 [17] | Prospective, observational | 17 | Mean age 38, APACHE II score 23, PaO2/FiO2 ratio 69, OI 49 | 5.1 | 30-day mortality 53% | 33 | 3 (17.6%) HFOV patients withdrawn for hypotension |
Claridge and colleagues, 1999 [30] | Prospective, observational | 5 | Trauma patients; mean age 37, APACHE II score 28, PaO2/FiO2 ratio 52 | 1.4 | 20% | 0 | None reported |
Mehta and colleagues, 2001 [18] | Prospective, observational | 24 | Mean age 48, APACHE II score 22, PaO2/FiO2 ratio 99, OI 32 | 5.7 | 30-day mortality 66% | 6 | 2 patients (8.3%) had pneumothorax |
Derdak and colleagues, 2002 [23] | Randomized controlled trial | 148 | Mean age 50, APACHE II score 22, PaO2/FiO2 ratio 112, OI 25 | 2.8 | 30-day mortality: HFOV 37%, CV 52% | 16 in both arms | Similar in both groups |
Andersen and colleagues, 2002 [25] | Retrospective | 16 | Mean age 38, SAPS II score 40, PaO2/FiO2 ratio 92, OI 28 | 7.2 | 3-month mortality 31% | Not reported | 1 (6.3%) patient had pneumothorax |
David and colleagues, 2003 [26] | Prospective, observational | 42 | Median age 49, APACHE II score 28, PaO2/FiO2 ratio 94, OI 23 | 3.0 | 30-day mortality 43% | 33 | 1 (2.4%) patient had pneumothorax |
Cartotto and colleagues, 2004 [29] | Retrospective | 25 | Burn patients; mean age 44, APACHE II score 17 | 4.8 | Inhospital mortality 32% | 4 | 3 (12%) patients had severe hypercapnea |
Mehta and colleagues, 2004 [28] | Retrospective | 156 | Median age 48, APACHE II score 24, PaO2/FiO2 ratio 91, OI 31 | 5.6 | 30-day mortality 62% | Not reported | 34 (21.8%) patients had pneumothorax |
Bollen and colleagues, 2005 [24] | Randomized controlled trial | 61 | Mean age 81, APACHE II score 21, HFOV 37 patients, CV 24 patients, OI 22 | 2.1 | HFOV 43%, CV 33% | 0 in both arms | HFOV: 4 (10.8%) patients had hypotension, 1 (2.7%) patient had air leak; CV: 1 (4.2%) patient had hypotension, 1 (4.2%) patient had air leak |
Ferguson and colleagues, 2005 [42] | Prospective | 25 | Mean age 50, APACHE II score 24, PaO2/FiO2 ratio 121, OI 23 | 0.5 | 44% in intensive care unit | Not assessed | 5 (25%) patients had barotrauma |
Pachl and colleagues, 2006 [20] | Prospective, observational | 30 | Mean age 55, SOFA score 9.6, PaO2/FiO2 ratio 121, OI 26 | 7.7 | 46.7% | Not reported | Not reported |
Finkielman and colleagues, 2006 [27] | Retrospective | 14 | Mean age 56, APACHE II score 35, PaO2/FiO2 ratio 73, OI 35 | 1.7 | 30-day mortality 57% | Not reported | 1 patient had HFOV discontinued for haemodynamic instability |