Neutrophil apoptosis: a marker of disease severity in sepsis and sepsis-induced acute respiratory distress syndrome

Table 4 Characteristics of the medical patients

	Uncomplicated sepsis (n = 8)	Septic shock (n = 12)	Sepsis-induced ARDS (n = 9)	Mechanical ventilation (n = 11)	Controls (n = 33)	P value
Age (years, mean ± SEM)	50.8 ± 4.9	56 ± 5.6	43.2 ± 5.8	57.5 ± 4.9	37.1 ± 1.7	<0.008^a
Male/Female (percentage)	50.0/50.0	58.3/41.7	44.4/55.6	36.4/63.6	48.5/51.5	0.7^b
APACHE II score (percentage)	13.6 ± 2.2	21 ± 2.2	21.5 ± 1.2	-	-	0.1
Maximum SOFA score (percentage)	4.7 ± 0.7	9.9 ± 1.0	12 ± 0.8	-	-	<0.001^a
Organ dysfunction (percentage)
0	50	25	0	-	-	-
1	0	16.7	77.8	-	-	-
2	25	41.7	0	-	-	-
3	25	16.7	22.2	-	-	-
Organ failure (percentage)
0	25	0	0	-	-	-
1	62.5	25	0	-	-	-
2	12.5	41.7	55.6	-	-	-
3	0	33.3	33.3	-	-	-
4	0	0	11.1	-	-	-
Mortality in 28 days (percentage)	37.5	75	77.8	-	-	-
Neutrophil apoptosis (mean percentage ± SEM)	57 ± 3.2	38 ± 3.7	28 ± 3.3	53 ± 3.0	69 ± 1.1	<0.001^a

^aP value from the comparisons using analysis-of-variance test; ^bp value from the comparisons using χ² test. APACHE II, Acute Physiology and Chronic Health Disease Classification System II; ARDS, acute respiratory distress syndrome; SEM, standard error of the mean; SOFA, sequential organ failure assessment.

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