Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia

Table 3 Changes in urinary output and hemoglobin concentration in endotoxemic sheep.

Variable	Group	T1	T2	T3	T4	T5	T6
Urinary output (ml h^-1)	Control	63 ± 5	94 ± 12	85 ± 13	n/a	n/a	97 ± 17
	AVP	66 ± 12	108 ± 14	246 ± 41***	n/a	n/a	192 ± 22**
	AVP-Dobu	69 ± 8	105 ± 14	264 ± 33***	n/a	n/a	252 ± 24***
Hemoglobin (g dl^-1)	Control	10.9 ± 0.3	10.5 ± 0.4	10.4 ± 0.3	10.4 ± 0.4	10.3 ± 0.3	10.2 ± 0.4
	AVP	10.5 ± 0.4	10.3 ± 0.3	10.1 ± 0.3	10.2 ± 0.3	10.4 ± 0.4	10.3 ± 0.4
	AVP-Dobu	10.5 ± 0.4	10.2 ± 0.3	9.9 ± 0.3	10.1 ± 0.5	10.7 ± 0.5	10.1 ± 0.5

AVP, arginine vasopressin; AVP-Dobu, group treated with AVP and dobutamine; T1, healthy baseline; T2, endotoxemic baseline; T3, AVP or placebo; T4, T5, T6, AVP + dobutamine 2, 5 and 10 μg kg^-1 min^-1 or placebo, respectively. ***p < 0.001 versus control.

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