Dobutamine reverses the vasopressin-associated impairment in cardiac index and systemic oxygen supply in ovine endotoxemia

Table 2 Changes in variables of acid-base balance and arterial lactate in endotoxemic sheep.

Variable	Group	T1	T2	T3	T4	T5	T6
Arterial pH	Control	7.46 ± 0.00	7.47 ± 0.00	7.46 ± 0.00	7.47 ± 0.00	7.47 ± 0.00	7.47 ± 0.00
	AVP	7.45 ± 0.02	7.47 ± 0.02	7.45 ± 0.03	7.46 ± 0.02	7.48 ± 0.02	7.47 ± 0.02
	AVP-Dobu	7.45 ± 0.02	7.47 ± 0.01	7.45 ± 0.01	7.45 ± 0.01	7.45 ± 0.01	7.44 ± 0.01
Arterial BE (mmol l^-1)	Control	4.4 ± 0.5	4.5 ± 0.9	4.9 ± 1	4.6 ± 1	4.1 ± 1	4.2 ± 1
	AVP	2.4 ± 1.5	4.0 ± 1.0	3.1 ± 1.4	3.8 ± 1.5	3.1 ± 1.3	3.2 ± 1.3
	AVP-Dobu	3.2 ± 0.9	3.2 ± 1	2.3 ± 1	2.1 ± 1.2	1.7 ± 1.2	1.5 ± 1.3
Arterial lactate (mmol l^-1)	Control	0.7 ± 0.1	1.6 ± 0.2^‡‡‡	1.6 ± 0.1	1.8 ± 0.2	1.9 ± 0.2	2.1 ± 0.2
	AVP	0.6 ± 0.1	1.4 ± 0.3^‡‡	1.4 ± 0.3	1.6 ± 0.4	1.6 ± 0.4	1.8 ± 0.4
	AVP-Dobu	0.8 ± 0.1	1.5 ± 0.2^‡‡‡	1.7 ± 0.3	1.4 ± 0.2	1.6 ± 0.1	2.0 ± 0.2
VO₂I (ml min^-1 m^-2)	Control	332 ± 20	336 ± 20	335 ± 20	336 ± 19	346 ± 17	339 ± 17
	AVP	317 ± 12	357 ± 37	287 ± 21	287 ± 21	303 ± 25	307 ± 13
	AVP-Dobu	316 ± 16	333 ± 17	265 ± 13	306 ± 17	328 ± 16	361 ± 15
Temperature (°C)	Control	39.5 ± 0.1	41.0 ± 0.2^‡‡‡	41.0 ± 0.1	41.0 ± 0.2	41.0 ± 0.2	41.0 ± 0.2
	AVP	39.7 ± 0.1	40.7 ± 0.2^‡‡‡	40.7 ± 0.2	40.7 ± 0.2	40.7 ± 0.1	40.7 ± 0.1
	AVP-Dobu	39.5 ± 0.1	41.0 ± 0.2^‡‡‡	40.9 ± 0.2	40.9 ± 0.2	40.8 ± 0.1	40.9 ± 0.2

AVP, arginine vasopressin; AVP-Dobu, group treated with AVP and dobutamine; BE, base excess; T1, healthy baseline; T2, endotoxemic baseline; T3, AVP or placebo; T4, T5, T6, AVP + dobutamine 2, 5 and 10 μg kg^-1 min^-1 or placebo, respectively. ^‡‡p < 0.01 versus T1, ^‡‡‡p < 0.001 versus T1.

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