Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study

Table 3 Requirement for vasoactive infusions on day 1

Parameter	Vasoactive infusions	No vasoactive infusions	p
Total patients	31 (66)	16 (34)
Death	13 (42)	1 (6)	0.01
IL-6	354 (189–768)	293 (87–657)	ns
pH	7.31 (7.26–7.35)	7.32 (7.29–7.40)	ns
Lactate	3.5 (1.9–6.02)	1.8 (1.05–3.75)	0.018
Base excess	-3.5 (-9 to 3.4)	-2 (-4.95 to 0.55)	ns
SOFA	9 (8–12)	4 (3.25–4.75)	<0.0001
SAPS2	47 (38–63)	33.5 (21–41.75)	0.003
ADMA	0.96 (0.82–1.29)	0.54 (0.48–0.78)	0.001
WCC	14 (8–22)	17 (8–24)	ns
MAP	65 (60–70)	79 (66–80)	0.001
Heart rate	110 (90–120)	103 (96–118)	ns
CVP	13 (10–16)	11 (7–12)	ns
Noradrenaline	13 (5–26)	-

All values are shown either as absolute counts with percentages in parenthesis or as medians with interquartile ranges in parenthesis. IL-6 was measured in pg/ml, asymmetrical dimethyl arginine (ADMA) in μmol/l, lactate in mmol/l, and mean arterial pressure (MAP) and central venous pressure (CVP) in mmHg. Noradrenaline dosage was measured in μg/minute. SOFA, Sequential Organ Failure Assessment score; SAPS, simplified acute physiology score; WCC, white cell count; ns, not significant.

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