Septic shock is correlated with asymmetrical dimethyl arginine levels, which may be influenced by a polymorphism in the dimethylarginine dimethylaminohydrolase II gene: a prospective observational study

Table 4 Use of vasoactive infusions on day 7

Parameter	Vasoactive infusions	No vasoactive infusions	p
Total patients	10 (24)	31 (76)
Death	5 (50)	3 (10)	0.005
IL-6	299 (20–784)	23 (0–117)	0.037
pH	7.36 (7.23–7.41)	7.44 (7.40–7.45)	0.0006
Lactate	2.35 (1.48–3.73)	1.2 (1–1.8)	0.006
Base excess	0.05 (4.7–3.8)	2.9 (1.1–4.8)	0.04
SOFA	11 (10–15)	4 (2.3–5.8)	<0.0001
ADMA	1.21 (0.88–1.57)	1 (0.66–1.18)	ns
WCC	18.2 (13.3–22.2)	10 (8.2–13.8)	0.01
MAP	70 (69–76)	82 (80–90)	0.01
Heart rate	100 (85–111)	78 (70–90)	0.04
CVP	11 (10–12)	10 (9–14)	ns
Noradrenaline	12 (4–21)	-

All values are shown either as absolute counts with percentages in parenthesis or as medians with interquartile ranges in parenthesis. IL-6 was measured in pg/ml, asymmetrical dimethyl arginine (ADMA) in μmol/l, lactate in mmol/l, and mean arterial pressure (MAP) and central venous pressure (CVP) in mmHg. Noradrenaline dosage was measured in μg/minute. SOFA, Sequential Organ Failure Assessment score; WCC, white cell count; ns, not significant.

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