From: Alternative protocol to initiate high-frequency oscillatory ventilation: an experimental study
 | Descent continuous distending pressure trial | |||||
---|---|---|---|---|---|---|
 | 45 mbar | 40 mbar | 35 mbar | 30 mbar | 25 mbar | 20 mbar |
Heart rate (beats/minute) | 141.5 (126–167) | 135.5 (112–153) | 128 (113–149) | 126 (107–147) | 115 (102–140) | 116 (104.5–128.5) |
Right atrial pressure (mmHg) | 16 (15–18) | 15 (14–15) | 14.5 (13–15) | 13.5 (12–15) | 12.5 (11–13) | 11.5 (10–13)†,**,* |
Mean pulmonary artery pressure (mmHg) | 41 (35.7–52) | 39 (35–41) | 39 (31–44) | 41 (35–42) | 39 (35–43) | 38.5 (36–42) |
Pulmonary occlusion pressure (mmHg) | 24 (23–26) | 21.5 (20–24) | 20 (18–21) | 17 (16.2–18.7) | 14 (13.5–17)†| 13.5 (12–15)†,** |
Left ventricular end-diastolic pressure (mmHg) | 11.5 (11–13) | 9 (9–11) | 9.5 (6–10) | 7.5 (6–12) | 7.5 (5–10)†| 5 (4–6)†|
Mean arterial pressure (mmHg) | 85 (66–89) | 70 (63–90) | 74 (67–104) | 74.5 (66–101) | 78.5 (77–108) | 84 (47–106) |
Cardiac output (l/minute) | 2.6 (2.3–3.1) | 2.6 (2–3) | 2.65 (2.28–3.36) | 2.52 (2.2–3.6) | 2.7 (2.2–4.2) | 3.1 (1.8–4.8) |
Stroke volume (ml) | 19 (18–24) | 21 (16.6–24.5) | 23.6 (15–29) | 23 (15–26.9) | 18.2 (16–33) | 18.7 (12.8–37) |
Intrathoracic blood volume (ml) | 442.5 (401–469) | 395 (335–495) | 485 (431–531) | 506.5 (453–542) | 552 (412–618) | 540 (492–614) |
Extravascular lung water (ml) | 355 (315–476) | 360 (331–441) | 405 (287–430) | 426 (336–495) | 441 (406.5–535) | 460 (390–549) |
Systemic vascular resistance (dyn*s/cm5) | 2,403 (1,524–2,585) | 1,598 (1,582–2,271) | 1,835 (1,567–1,997) | 2,026 (1,442–2,033) | 1,933 (1,303–2,469) | 1,611 (1,238–2,056) |
Pulmonary vascular resistance (dyn*s/cm5) | 639 (404–859) | 440 (396–663) | 457 (376–663) | 512 (461–746) | 617 (418–970) | 678 (415–1,065) |
Mean pulmonary artery pressure–right atrial pressure (mmHg) | 28 (19–34) | 25.5 (23–26) | 25 (18–29) | 27.5 (26–28) | 27 (25–30) | 28.5 (23–31) |
Transpulmonary pressure (mbar) | 36 (32–43) | 31 (27–38) | 26.5 (22–33) | 21.5 (17–28) | 14.5 (12–22)†,** | 10 (7–18)†,** |
PaO2 (Torr) | 621 (619–660) | 654 (645–683) | 664 (636–694) | 644 629–692) | 615 (469–680) | 429 (52–558)** |
PaO2/FiO2 ratio | 82.8 (82.5–88) | 654 (645–683) | 664 (636–694) | 644 629–692) | 615 (469–680) | 429 (52–558)** |
Oxygenation index | 7.2 (6.8–7.2) | 6.1 (5.8–6.1) | 5.4 (5–5.5) | 4.6 (4.3–4.7) | 4 (3.6–5.3) | 4.8 (3.5–37.9) |
Oxygen delivery (ml O2/minute) | 312.5 (299–466) | 358.2 (305.6–420) | 360 (349–418) | 357.2 (338–447) | 347.4 (292–516) | 399.6 (251–548) |
Shunt proportion | 1.03 (0.4–3) | 0.7 (0.1–1.4) | 1.5 (0–4.3) | 1.6 (1.1–4.9) | 4.7 (4.2–11.3) | 20.2 (7.2–52)†,** |
PaCO2 (Torr) | 38.5 (28.3–46.6) | 40.3 (30.1–51.1) | 37.4 (30.7–44.8) | 41.2 (31.1548) | 46.9 (32.9–61.2) | 54.5 (40.7–68.6)†,* |
Oxygen saturation (%) | 99.9 (99–100) | 99.9 (99.8–100) | 99.9 (99.9–100) | 99.9 (98.3–100) | 99.9 (96–100) | 99.8 (83–99) |
pH | 7.41 (7.37–7.5) | 7.4 (7.34–7.53) | 7.4 (7.38–7.51) | 7.4 (7.38–7.51) | 7.38 (7.35–7.48) | 7.29 (7.25–7.4) |
Standard bicarbonate (mmol/l) | 25 (24.2–29.8) | 25.8 (25–27) | 26 (23.4–27.6) | 25.1 (23.5–27.7) | 25.3 (24.2–28.5) | 24.6 (24.1–28.5) |
Base excess | 0.95 (0.4–6.2) | 1 (-1.5 to 5.2) | 02 (-0.65 to 2.97) | -0.15 (-2.4 to 1.6) | -1.35 (-2.3 to 1.4) | 0.2 (-4.25 to 0.47) |
Hemoglobin (g/dl) | 7.9 (7.1–9.7) | 8.8 (7.4–10.1) | 8.2 (7.5–10.4) | 8 (7.4–9.7) | 7.9 (7.1–9.4) | 7.8 (7–10) |