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Table 2 Hemodynamic data and blood gas data on every continuous distending pressure in high-frequency oscillatory ventilation study protocol

From: Alternative protocol to initiate high-frequency oscillatory ventilation: an experimental study

 

Descent continuous distending pressure trial

 

45 mbar

40 mbar

35 mbar

30 mbar

25 mbar

20 mbar

Heart rate (beats/minute)

141.5 (126–167)

135.5 (112–153)

128 (113–149)

126 (107–147)

115 (102–140)

116 (104.5–128.5)

Right atrial pressure (mmHg)

16 (15–18)

15 (14–15)

14.5 (13–15)

13.5 (12–15)

12.5 (11–13)

11.5 (10–13)†,**,*

Mean pulmonary artery pressure (mmHg)

41 (35.7–52)

39 (35–41)

39 (31–44)

41 (35–42)

39 (35–43)

38.5 (36–42)

Pulmonary occlusion pressure (mmHg)

24 (23–26)

21.5 (20–24)

20 (18–21)

17 (16.2–18.7)

14 (13.5–17)†

13.5 (12–15)†,**

Left ventricular end-diastolic pressure (mmHg)

11.5 (11–13)

9 (9–11)

9.5 (6–10)

7.5 (6–12)

7.5 (5–10)†

5 (4–6)†

Mean arterial pressure (mmHg)

85 (66–89)

70 (63–90)

74 (67–104)

74.5 (66–101)

78.5 (77–108)

84 (47–106)

Cardiac output (l/minute)

2.6 (2.3–3.1)

2.6 (2–3)

2.65 (2.28–3.36)

2.52 (2.2–3.6)

2.7 (2.2–4.2)

3.1 (1.8–4.8)

Stroke volume (ml)

19 (18–24)

21 (16.6–24.5)

23.6 (15–29)

23 (15–26.9)

18.2 (16–33)

18.7 (12.8–37)

Intrathoracic blood volume (ml)

442.5 (401–469)

395 (335–495)

485 (431–531)

506.5 (453–542)

552 (412–618)

540 (492–614)

Extravascular lung water (ml)

355 (315–476)

360 (331–441)

405 (287–430)

426 (336–495)

441 (406.5–535)

460 (390–549)

Systemic vascular resistance (dyn*s/cm5)

2,403 (1,524–2,585)

1,598 (1,582–2,271)

1,835 (1,567–1,997)

2,026 (1,442–2,033)

1,933 (1,303–2,469)

1,611 (1,238–2,056)

Pulmonary vascular resistance (dyn*s/cm5)

639 (404–859)

440 (396–663)

457 (376–663)

512 (461–746)

617 (418–970)

678 (415–1,065)

Mean pulmonary artery pressure–right atrial pressure (mmHg)

28 (19–34)

25.5 (23–26)

25 (18–29)

27.5 (26–28)

27 (25–30)

28.5 (23–31)

Transpulmonary pressure (mbar)

36 (32–43)

31 (27–38)

26.5 (22–33)

21.5 (17–28)

14.5 (12–22)†,**

10 (7–18)†,**

PaO2 (Torr)

621 (619–660)

654 (645–683)

664 (636–694)

644 629–692)

615 (469–680)

429 (52–558)**

PaO2/FiO2 ratio

82.8 (82.5–88)

654 (645–683)

664 (636–694)

644 629–692)

615 (469–680)

429 (52–558)**

Oxygenation index

7.2 (6.8–7.2)

6.1 (5.8–6.1)

5.4 (5–5.5)

4.6 (4.3–4.7)

4 (3.6–5.3)

4.8 (3.5–37.9)

Oxygen delivery (ml O2/minute)

312.5 (299–466)

358.2 (305.6–420)

360 (349–418)

357.2 (338–447)

347.4 (292–516)

399.6 (251–548)

Shunt proportion

1.03 (0.4–3)

0.7 (0.1–1.4)

1.5 (0–4.3)

1.6 (1.1–4.9)

4.7 (4.2–11.3)

20.2 (7.2–52)†,**

PaCO2 (Torr)

38.5 (28.3–46.6)

40.3 (30.1–51.1)

37.4 (30.7–44.8)

41.2 (31.1548)

46.9 (32.9–61.2)

54.5 (40.7–68.6)†,*

Oxygen saturation (%)

99.9 (99–100)

99.9 (99.8–100)

99.9 (99.9–100)

99.9 (98.3–100)

99.9 (96–100)

99.8 (83–99)

pH

7.41 (7.37–7.5)

7.4 (7.34–7.53)

7.4 (7.38–7.51)

7.4 (7.38–7.51)

7.38 (7.35–7.48)

7.29 (7.25–7.4)

Standard bicarbonate (mmol/l)

25 (24.2–29.8)

25.8 (25–27)

26 (23.4–27.6)

25.1 (23.5–27.7)

25.3 (24.2–28.5)

24.6 (24.1–28.5)

Base excess

0.95 (0.4–6.2)

1 (-1.5 to 5.2)

02 (-0.65 to 2.97)

-0.15 (-2.4 to 1.6)

-1.35 (-2.3 to 1.4)

0.2 (-4.25 to 0.47)

Hemoglobin (g/dl)

7.9 (7.1–9.7)

8.8 (7.4–10.1)

8.2 (7.5–10.4)

8 (7.4–9.7)

7.9 (7.1–9.4)

7.8 (7–10)

  1. Data presented as median (25th–75th percentiles). Significant differences in parameters are indicated: *P < 0.05 vs 35 mbar, **P < 0.05 vs 40 mbar, †P < 0.05 vs 45 mbar.