Figure 5
From: Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction
Plasma cytokine response. Plasma concentrations of KC (a), macrophage inflammatory protein-2 (MIP-2) (b), IL-6 (c), and TNF-α (d) in mice treated with intraperitoneal PBS followed 14 hours later by 6 hours of spontaneous breathing (PBS) or mechanical ventilation (MV), and in mice treated with intraperitoneal lipopolysaccharide (LPS; 1 μg/kg) followed 14 hours later by either spontaneous breathing (LPS) or 6 hours of mechanical ventilation (LPS + MV). In all groups receiving mechanical ventilation, the tidal volume was 10 ml/kg and the fraction of inspired oxygen was 0.21. *p < 0.05.