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Table 3 Biomarker levels pre-intubation and at two time points post-intubation

From: Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury

Biological marker

Reference standard, mean (range)

Pre-intubation, median (range)

0 to 8 hours post-intubation, median (range)

12 to 26 hours post-intubation, median (range)

p valuea

IL-6 (pg/ml)

43 (0 to 149)

76 (3 to 652)

132 (4 to 971)

90 (3 to 550)

0.34

IL-8 (pg/ml)

9 (1.2 to 16.7)

235 (10 to 1,836)

219 (10 to 2,115)

68 (10 to 1,552)

0.0003b

ICAM-1 (ng/ml)

211 (115 to 306)

631 (220 to 2,800)

520 (198 to 3,970)

492 (221 to 1,780)

0.15

vWF

% control

368 (116 to 742)

312 (40 to 814)

359 (91 to 653)

0.58

  1. aRepeated measures analysis of variance comparing levels of cytokine at three different time points; bsee Figure 2. ICAM-1, intercellular adhesion molecule-1; IL, interleukin; vWF, von Willebrand factor.
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Critical Care

ISSN: 1364-8535