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Table 2 Effects of in vivo lipopolysaccharide (LPS) on isolated and perfused hearts of young rats and senescent rats

From: Endotoxin-induced myocardial dysfunction in senescent rats

 

Young rats (3 months old)

Senescent rats (24 months old)

 

Control group (n = 8)

LPS 0.5 mg/kg group (n = 9)

LPS 5 mg/kg group (n = 9)

Control group (n = 11)

LPS 0.5 mg/kg group (n = 13)

LVDP (mmHg/g HW)

100 ± 7

64 ± 6*

48 ± 7*

53 ± 4

25 ± 4*

dP/dtmax (mmHg/s/g HW)

2744 ± 186

1611 ± 138*

1216 ± 152*

1804 ± 260

893 ± 158*

-dP/dtmax (mmHg/s/g HW)

-1863 ± 61

-1320 ± 116*

-1058 ± 103*

-919 ± 91

-480 ± 59*

Coronary flow (ml/minute/g HW)

14 ± 2

14 ± 1

13 ± 2

10 ± 1

12 ± 1

  1. Values are the mean ± standard error of the mean. LVDP, left ventricular developed pressure; dP/dtmax, peak of the positive pressure derivative; -dP/dtmax, peak of the negative pressure derivative. *P < 0.05 versus respective control (saline-injected) group.
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Critical Care

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