Reference | Year | ICU-acquired pneumonia (time of evaluation) | Mortality due to pneumonia (time of evaluation) | All cause mortality (time of evaluation) | Proportion of patients with colonization of respiratory tract by P. aeruginosa | Emergence of resistance | Toxicity |
---|---|---|---|---|---|---|---|
Wood et al. [21] | 2002 | 3/20 (15%) vs 11/20 (55%) (day 14); 6/20 (30%) vs 13/20 (65%) (entire ICU stay) | NA | 3/20 (15%) vs 6/20 (30%) (entire ICU stay) | No data | No clinically significant changes in bacterial sensitivity patternsa | None |
Rouby et al. [19] | 1994 | 97/347 (28%) vs 100/251 (40%) (week 2) | NA | 42/347 (12%) vs 31/251 (12%) (week 2) | No data | Not observeda | Not mentioned |
Rathgeber et al. [18] | 1993 | 5/29 (17%) vs 17/40 (43%) (entire ICU stay) | 2/29 (7%) vs 4/40 (10%) (entire ICU stay) | 4/29 (14%) vs 8/40 (20%) (entire ICU stay) | 2/171 (1%) vs 44/215 (20%)b | Non-significantly higher incidence mainly of S. epidermidisa | None |
Lode et al. [17] | 1992 | 29/85 (34%) vs 25/77 (32%) (day 16) | NA | 23/85 (27%) vs 25/77 (39%) (week 4) | 2/85 (2%) vs 6/77 (8%) | No data | Not mentioned |
Vogel et al. [20] | 1981 | Less frequent in the gentamicin group | NA | No data | 5/20 (25%) vs 9/20 (45%) | No evidence of increasea | Not mentioned |
Klick et al. [15] | 1975 | 16/355 (5%) vs 24/337 (7%) (entire ICU stay) | 5/374 (1%) vs 2/370 (0.5%) (entire ICU stay) | 45/374 (12%) vs 45/370 (12%) (entire ICU stay) | 6/374 (2%) vs 36/370 (10%) | Did not occur to any significant extenta | Not mentioned |
Klastersky et al. [13] | 1974 | 5/43 (12%) vs 17/42 (40%) (entire ICU stay) | 2/43 (5%) vs 4/42 (10%) (entire ICU stay) | 23/43 (54%) vs 16/42 (38%) (entire ICU stay) | 39/228 (17%) vs 32/174 (18%)b | The isolated microorganisms from the drug group were slightly more resistant to gentamicina | Not mentioned |
Greenfield et al. [11] | 1973 | 2/33 (6%) vs 4/25 (16%) (entire ICU stay) | NA | 4/33 (12%) vs 6/25 (24%) (entire ICU stay) | 0/33 (0%) vs 3/25 (12%) | Not encountered frequently (only six Gram-negative bacteria resistant to polymyxin)a | Negligiblea |