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Table 4 Arterial lactate; systemic and regional lactate/pyruvate ratios; regional lactate exchange

From: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function

  Group Baseline 1.5 hours 3 hours 6 hours 12 hours End of experiment
Arterial lactate (mmol/l) Endotoxic 0.8 (0.4–1.2) 1.0 (0.5–1.3) 0.9 (0.7–1.7) 0.9 (0.7–1.1) 0.8 (0.5–1.0) 0.9 (0.6–4.2)
  Control 0.9 (0.7–1.2) 0.7 (0.5–1.2) 0.7 (0.5–1) 0.7 (0.5–1.0) 0.5 (0.4–0.8) 0.5 (0.3–1.1)
Systemic lactate/pyruvate ratio Endotoxic 9.4 (6.7–17.0) 9.5 (7.1–18.3) 11.0 (6.7–23.7) 8.9 (7.5–14.1) 9.5 (6.6–10.4) 11.9 (8.5–27.1)a
  Control 9.5 (5.7–13.6) 8.1 (5.4–10.0) 8.7 (7.1–10.9) 8.7 (7.2–11.3) 8.5 (5.4–11.8) 7.3 (5.6–11.6)
Hepatic lactate/pyruvate ratio Endotoxic 9.7 (7.3–27.6) 10.3 (5.7–19.8) 10.7 (6.9–18.6) 9.4 (6.2–18.1) 7.9 (6.2–16.7) 12.1 (7.5–33.0)
  Control 12.4 (3.9–46.9) 9.2 (4.5–26.7) 9.9 (6.7–34.9) 8.2 (5.4–28.3) 7.0 (4.9–30.8) 9.2 (5.8–25.3)
Renal lactate/pyruvate ratio Endotoxic 8.0 (6.0–10.0) 8.4 (5.5–35.9) 9.8 (6.6–12.5) 8.0 (5.4–15.7) 7.4 (6.3–9.8) 8.1 (7.3–33.6)
  Control 8.7 (6.5–11.0) 7.9 (5.7–13.1) 8.6 (6.1–14.4) 8.7 (5.2–36.1) 7.3 (5.8–37.3) 8.7 (5.3–14.2)
Renal lactate exchange (μmol/minute) Endotoxic 1.4 (–1.5–2.1) 1.0 (–12.1–1.6) 0.9 (–3.2–2.4) 0.6 (–0.9–1.2) 0.8 (–0.7–2.6) 1.1 (–7.8–2.4)
  Control 0.7 (–3.5–1.6) 0.1 (–4.5–1.5) 0.3 (–1.7–1.3) 0.6 (–11.1–1.3) 0.5 (–9.9–1.5) 0.3 (–1.5–1.4)
Hepatic lactate exchange (μmol/kg/minute) Endotoxic 9.0 (5.2–20.1) 8.7 (–11.0–22.4) 9.7 (7.4–21.3) 11.6 (9.6–19.0) 12.7 (6.5–18.6) 10.8 (–17.5–15.2)
  Control 10.3 (0.8–18.2) 9.0 (5.9–15.0) 8.6 (3.8–19.0) 7.3 (4.7–16.9) 9.2 (3.5–16.7) 9.4 (5.2–16.7)
  1. Data presented as the median (range).