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Table 3 Regional flows, microcirculation, and systemic and regional oxygen extraction and consumption

From: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function

 

Group

Baseline

1.5 hours

3 hours

6 hours

12 hours

End of experiment

Renal blood flow (ml/kg/minute)

Endotoxic

7.7 (2.3–10.5)

7.3 (2.2–11.6)

6.2 (2.4–9.5)

6.1 (2.4–10.0)

5.8 (2.7–10.8)

3.9 (0.9–10.8)b

 

Control

5.7 (1.9–9.5)

5.6 (2.4–8.2)

5.6 (2.9–7.6)

6.0 (2.9–8.1)

6.3 (3.0–7.9)

5.1 (3.3–8)

Total hepatic blood flow (ml/kg/minute)

Endotoxic

23.2 (13.5–29.3)

22.7 (16.7–27.6)

25.5 (14–36.9)

26.9 (23.3–31.6)

26.7 (21.1–40)a

24.5 (19.7–39.6)

 

Control

21.5 (17.5–30)

23.7 (17.5–25)

24.8 (18.6–28)

22.5 (21.3–28.1)

26.1 (17.5–29)

25.3 (23.5–42.3)

Liver blood perfusion units (%)

Endotoxic

100

104 (58–229)

111 (48–212)

97 (51–238)

86 (27–212)

70 (22–194)

 

Control

100

112 (62–156)

122 (53–221)

94 (43–282)

94 (65–376)

93 (27–251)

Renal blood perfusion units (%)

Endotoxic

100

101 (28–170)

100 (37–141)

89 (31–151)

93 (42–132)

45 (27–102)b

 

Control

100

71 (35–200)

93 (32–157)

62 (22–171)

90 (20–617)

55 (16–660)

Systemic VO2 (ml/kg/minute)

Endotoxic

6.5 (4.7–11.7)

7.1 (3.8–10.7)

7.7 (4.2–11.1)

7 (5.3–10.1)

7.8 (4.9–8.9)

6.9 (4.6–9.3)

 

Control

5.2 (4.5–8.4)

6.4 (3.9–7.9)

7.1 (3.2–8.1)

6.1 (3.6–8.9)

7.0 (3.9–8.2)

6.0 (3.8–8.1)

Hepatic VO2 (ml/kg/minute)

Endotoxic

0.9 (0.3–1.5)

1.0 (0.5–1.5)

1.1 (0.5–2.6)

1.3 (0.7–2.1)

1.1 (0.6–1.8)

1.1 (0.4–1.8)

 

Control

1.0 (0.8–2.0)

1.0 (0.9–1.2)

1.0 (0.7–1.2)

1.1 (0.9–1.5)

1.1 (0.8–1.4)

1.1 (0.7–1.7)

Renal VO2 (ml/kg/minute)

Endotoxic

0.2 (0.1–0.3)

0.2 (0.1–0.3)

0.2 (0.1–0.3)

0.2 (0.1–0.3)

0.3 (0.1–0.3)

0.2 (0.04–0.3)

 

Control

0.2 (0.1–0.3)

0.2 (0.1–0.2)

0.2 (0.1–0.2)

0.2 (0.2–0.2)

0.2 (0.2–0.3)

0.2 (0.1–0.3)

Systemic oxygen extraction (%)

Endotoxic

57 (43–71)

56 (41–74)

63 (39–73)

62 (47–70)

55 (42–66)

60 (50–88)

 

Control

57 (37–65)

56 (45–66)

59 (43–69)

57 (38–70)

54 (39–63)

50 (30–70)

Hepatic oxygen extraction (%)

Endotoxic

46 (35–82)

49 (21–78)

57 (27–84)

60 (33–74)

54 (34–66)

61 (30–74)

 

Control

60 (53–73)

62 (39–70)

58 (29–74)

56 (45–78)

61 (34–72)

53 (30–75)

Renal oxygen extraction (%)

Endotoxic

24 (17–37)

21 (18–41)

24 (20–30)

26 (25–53)

29 (21–42)a

36 (28–82)b

 

Control

25 (17–60)

22 (15–55)

24 (17–52)

26 (19–54)

24 (21–58)

30 (24–52)

  1. Data presented as the median (range). aFriedman test first 12 hours, P < 0.01. bWilcoxon test, P < 0.05 vs 12 hours.