From: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function
Group | Baseline | 1.5 hours | 3 hours | 6 hours | 12 hours | End of experiment | |
---|---|---|---|---|---|---|---|
Renal blood flow (ml/kg/minute) | Endotoxic | 7.7 (2.3–10.5) | 7.3 (2.2–11.6) | 6.2 (2.4–9.5) | 6.1 (2.4–10.0) | 5.8 (2.7–10.8) | 3.9 (0.9–10.8)b |
Control | 5.7 (1.9–9.5) | 5.6 (2.4–8.2) | 5.6 (2.9–7.6) | 6.0 (2.9–8.1) | 6.3 (3.0–7.9) | 5.1 (3.3–8) | |
Total hepatic blood flow (ml/kg/minute) | Endotoxic | 23.2 (13.5–29.3) | 22.7 (16.7–27.6) | 25.5 (14–36.9) | 26.9 (23.3–31.6) | 26.7 (21.1–40)a | 24.5 (19.7–39.6) |
Control | 21.5 (17.5–30) | 23.7 (17.5–25) | 24.8 (18.6–28) | 22.5 (21.3–28.1) | 26.1 (17.5–29) | 25.3 (23.5–42.3) | |
Liver blood perfusion units (%) | Endotoxic | 100 | 104 (58–229) | 111 (48–212) | 97 (51–238) | 86 (27–212) | 70 (22–194) |
Control | 100 | 112 (62–156) | 122 (53–221) | 94 (43–282) | 94 (65–376) | 93 (27–251) | |
Renal blood perfusion units (%) | Endotoxic | 100 | 101 (28–170) | 100 (37–141) | 89 (31–151) | 93 (42–132) | 45 (27–102)b |
Control | 100 | 71 (35–200) | 93 (32–157) | 62 (22–171) | 90 (20–617) | 55 (16–660) | |
Systemic VO2 (ml/kg/minute) | Endotoxic | 6.5 (4.7–11.7) | 7.1 (3.8–10.7) | 7.7 (4.2–11.1) | 7 (5.3–10.1) | 7.8 (4.9–8.9) | 6.9 (4.6–9.3) |
Control | 5.2 (4.5–8.4) | 6.4 (3.9–7.9) | 7.1 (3.2–8.1) | 6.1 (3.6–8.9) | 7.0 (3.9–8.2) | 6.0 (3.8–8.1) | |
Hepatic VO2 (ml/kg/minute) | Endotoxic | 0.9 (0.3–1.5) | 1.0 (0.5–1.5) | 1.1 (0.5–2.6) | 1.3 (0.7–2.1) | 1.1 (0.6–1.8) | 1.1 (0.4–1.8) |
Control | 1.0 (0.8–2.0) | 1.0 (0.9–1.2) | 1.0 (0.7–1.2) | 1.1 (0.9–1.5) | 1.1 (0.8–1.4) | 1.1 (0.7–1.7) | |
Renal VO2 (ml/kg/minute) | Endotoxic | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.2 (0.1–0.3) | 0.3 (0.1–0.3) | 0.2 (0.04–0.3) |
Control | 0.2 (0.1–0.3) | 0.2 (0.1–0.2) | 0.2 (0.1–0.2) | 0.2 (0.2–0.2) | 0.2 (0.2–0.3) | 0.2 (0.1–0.3) | |
Systemic oxygen extraction (%) | Endotoxic | 57 (43–71) | 56 (41–74) | 63 (39–73) | 62 (47–70) | 55 (42–66) | 60 (50–88) |
Control | 57 (37–65) | 56 (45–66) | 59 (43–69) | 57 (38–70) | 54 (39–63) | 50 (30–70) | |
Hepatic oxygen extraction (%) | Endotoxic | 46 (35–82) | 49 (21–78) | 57 (27–84) | 60 (33–74) | 54 (34–66) | 61 (30–74) |
Control | 60 (53–73) | 62 (39–70) | 58 (29–74) | 56 (45–78) | 61 (34–72) | 53 (30–75) | |
Renal oxygen extraction (%) | Endotoxic | 24 (17–37) | 21 (18–41) | 24 (20–30) | 26 (25–53) | 29 (21–42)a | 36 (28–82)b |
Control | 25 (17–60) | 22 (15–55) | 24 (17–52) | 26 (19–54) | 24 (21–58) | 30 (24–52) |