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Table 3 Regional flows, microcirculation, and systemic and regional oxygen extraction and consumption

From: Effects of prolonged endotoxemia on liver, skeletal muscle and kidney mitochondrial function

  Group Baseline 1.5 hours 3 hours 6 hours 12 hours End of experiment
Renal blood flow (ml/kg/minute) Endotoxic 7.7 (2.3–10.5) 7.3 (2.2–11.6) 6.2 (2.4–9.5) 6.1 (2.4–10.0) 5.8 (2.7–10.8) 3.9 (0.9–10.8)b
  Control 5.7 (1.9–9.5) 5.6 (2.4–8.2) 5.6 (2.9–7.6) 6.0 (2.9–8.1) 6.3 (3.0–7.9) 5.1 (3.3–8)
Total hepatic blood flow (ml/kg/minute) Endotoxic 23.2 (13.5–29.3) 22.7 (16.7–27.6) 25.5 (14–36.9) 26.9 (23.3–31.6) 26.7 (21.1–40)a 24.5 (19.7–39.6)
  Control 21.5 (17.5–30) 23.7 (17.5–25) 24.8 (18.6–28) 22.5 (21.3–28.1) 26.1 (17.5–29) 25.3 (23.5–42.3)
Liver blood perfusion units (%) Endotoxic 100 104 (58–229) 111 (48–212) 97 (51–238) 86 (27–212) 70 (22–194)
  Control 100 112 (62–156) 122 (53–221) 94 (43–282) 94 (65–376) 93 (27–251)
Renal blood perfusion units (%) Endotoxic 100 101 (28–170) 100 (37–141) 89 (31–151) 93 (42–132) 45 (27–102)b
  Control 100 71 (35–200) 93 (32–157) 62 (22–171) 90 (20–617) 55 (16–660)
Systemic VO2 (ml/kg/minute) Endotoxic 6.5 (4.7–11.7) 7.1 (3.8–10.7) 7.7 (4.2–11.1) 7 (5.3–10.1) 7.8 (4.9–8.9) 6.9 (4.6–9.3)
  Control 5.2 (4.5–8.4) 6.4 (3.9–7.9) 7.1 (3.2–8.1) 6.1 (3.6–8.9) 7.0 (3.9–8.2) 6.0 (3.8–8.1)
Hepatic VO2 (ml/kg/minute) Endotoxic 0.9 (0.3–1.5) 1.0 (0.5–1.5) 1.1 (0.5–2.6) 1.3 (0.7–2.1) 1.1 (0.6–1.8) 1.1 (0.4–1.8)
  Control 1.0 (0.8–2.0) 1.0 (0.9–1.2) 1.0 (0.7–1.2) 1.1 (0.9–1.5) 1.1 (0.8–1.4) 1.1 (0.7–1.7)
Renal VO2 (ml/kg/minute) Endotoxic 0.2 (0.1–0.3) 0.2 (0.1–0.3) 0.2 (0.1–0.3) 0.2 (0.1–0.3) 0.3 (0.1–0.3) 0.2 (0.04–0.3)
  Control 0.2 (0.1–0.3) 0.2 (0.1–0.2) 0.2 (0.1–0.2) 0.2 (0.2–0.2) 0.2 (0.2–0.3) 0.2 (0.1–0.3)
Systemic oxygen extraction (%) Endotoxic 57 (43–71) 56 (41–74) 63 (39–73) 62 (47–70) 55 (42–66) 60 (50–88)
  Control 57 (37–65) 56 (45–66) 59 (43–69) 57 (38–70) 54 (39–63) 50 (30–70)
Hepatic oxygen extraction (%) Endotoxic 46 (35–82) 49 (21–78) 57 (27–84) 60 (33–74) 54 (34–66) 61 (30–74)
  Control 60 (53–73) 62 (39–70) 58 (29–74) 56 (45–78) 61 (34–72) 53 (30–75)
Renal oxygen extraction (%) Endotoxic 24 (17–37) 21 (18–41) 24 (20–30) 26 (25–53) 29 (21–42)a 36 (28–82)b
  Control 25 (17–60) 22 (15–55) 24 (17–52) 26 (19–54) 24 (21–58) 30 (24–52)
  1. Data presented as the median (range). aFriedman test first 12 hours, P < 0.01. bWilcoxon test, P < 0.05 vs 12 hours.