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Table 1 Baseline patient characteristics based on the time to treatment

From: Timing of drotrecogin alfa (activated) treatment in severe sepsis

Parameter

0–24 hours (n = 29)

>24 hours (n = 11)

P value

Age (years)

51.5 ± 17.6

67.4 ± 9.9

0.008a

Male sex

13 (45%)

3 (27%)

0.31b

Acute Physiology and Chronic Health Evaluation II score

23.9 ± 5.5

26.9 ± 9.8

0.22a

Time from first organ dysfunction to start of treatment (hours)

12.2 ± 6.8

45.7 ± 21.8

<0.0001a

Number of organ dysfunctions

3.6 ± 1.2

3.3 ± 1.3

0.55a

Mechanical ventilation

25 (86%)

11 (100%)

0.19b

Vasopressors

28 (97%)

10 (91%)

0.47b

Recent surgery

8 (28%)

6 (55%)

0.13b

Primary site of infection

   

   Respiratory system

13 (45%)

1 (9%)

0.03b

   Abdominal

8 (28%)

5 (45%)

0.28b

   Urogenital

2 (7%)

2 (18%)

0.29b

   Other

6 (2%)

3 (27%)

0.66b

  1. Data presented as mean ± standard deviation or as n (%). aStudent's t test. bChi-square test.