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Table 2 Demographic data and genotype frequencies of TNF and IL-10 polymorphisms in patients with sepsis and controls.

From: Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis

 

Patients (n = 224)

Control individuals (n = 101)

Age

63.5 (49–72.75)

50 (46.5–55.5)

APACHE II

14 (9–19)

-

SOFA (1)a

4 (2–9)

-

-308 TNF-α promoter polymorphism

   GG

186 (83)

82 (81.2)

   GA

35 (15.6)

15 (14.9)

   AA

3 (1.4)

4 (3.9)

TNF-β (Nco I polymorphism)

   GG

16 (7.1)

10 (9.9)

   GA

69 (30.8)

34 (33.7)

   AA

139 (62.5)

57 (56.4)

IL-10-1082

   GG

33 (14.8)

15 (14.8)

   GA

99 (44.2)

50 (49.5)

   AA

92 (41)

36 (35.7)

  1. Values are expressed as median (25th to 75th percentile) or as n (%).aSOFA (1) means SOFA score of the first 24 hours in the hospital. APACHE, Acute Physiology and Chronic Health Evaluation score; SOFA, Sequential Organ Failure Assessment; TNF, tumour necrosis factor.
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Critical Care

ISSN: 1364-8535